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Property and Equipment:
9 Months Ended
Sep. 30, 2022
Property, Plant and Equipment [Abstract]  
Property and Equipment [Text Block] Property, Plant and Equipment
Property, plant and equipment consists of the following (in thousands): 
As of
 September 30, 2022December 31, 2021
Machinery and equipment$409,349 $321,078 
Land, building and building improvements272,426 243,377 
Molds75,874 60,463 
Computer equipment and software114,378 102,979 
Furniture and fixtures29,110 7,670 
Instruments placed with customers(1)
106,245 97,384 
Construction in progress147,099 72,153 
Total property, plant and equipment, cost1,154,481 905,104 
Accumulated depreciation(498,098)(436,739)
Property, plant and equipment, net$656,383 $468,365 
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(1)    Instruments placed with customers consist of drug-delivery and monitoring systems placed with customers under operating leases.

Depreciation expense was $23.0 million and $69.4 million for the three and nine months ended September 30, 2022, respectively. Depreciation expense was $16.4 million and $49.1 million for the three and nine months ended September 30, 2021, respectively.

During the three and nine months ended September 30, 2022, property, plant and equipment and related depreciation expense increased significantly due to the acquisition of Smiths Medical (see Note 3: Acquisitions).