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Property and Equipment:
6 Months Ended
Jun. 30, 2022
Property, Plant and Equipment [Abstract]  
Property and Equipment [Text Block] Property, Plant and Equipment
Property, plant and equipment consists of the following (in thousands): 
As of
 June 30, 2022December 31, 2021
Machinery and equipment$407,580 $321,078 
Land, building and building improvements271,723 243,377 
Molds75,765 60,463 
Computer equipment and software115,371 102,979 
Furniture and fixtures29,538 7,670 
Instruments placed with customers(1)
110,592 97,384 
Construction in progress136,723 72,153 
Total property, plant and equipment, cost1,147,292 905,104 
Accumulated depreciation(479,509)(436,739)
Property, plant and equipment, net$667,783 $468,365 
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(1)    Instruments placed with customers consist of drug-delivery and monitoring systems placed with customers under operating leases.

Depreciation expense was $24.9 million and $46.4 million for the three and six months ended June 30, 2022, respectively. Depreciation expense was $16.3 million and $32.7 million for the three and six months ended June 30, 2021 and 2021, respectively.

During the three and six months ended June 30, 2022, property, plant and equipment and related depreciation expense increased significantly due to the acquisition of Smiths Medical (see Note 3: Acquisitions).