Note 13 - Income Taxes - Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Deferred tax assets:
Net federal and state operating losses	$ 101,600	$ 113,649
Research and development credits	86,321	71,197
Royalty income	115,554	106,007
Stock-based compensation	19,374	14,512
Capitalized R&D	62,794	8,997
Leasing obligations	1,842	1,836
Other	4,354	4,809
Total deferred tax assets	391,839	321,007
Deferred tax liabilities:
Fixed assets	(717)	(607)
Right of use asset	(1,525)	(1,527)
Total deferred tax liabilities	(2,242)	(2,134)
Valuation allowance	(389,608)	(318,714)
Net deferred tax assets (liabilities)	$ (11)
Net deferred tax assets (liabilities)		$ 159