Consolidated Statements of Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Revenues
Total revenues	$ 270,827	$ 157,170	$ 17,812
Expenses
Cost of products sold	6,408	7,229	1,550
Research and development	253,297	208,808	122,964
Selling, general and administrative	159,371	118,818	67,929
Royalty	186	35	126
Total operating expenses	419,262	334,890	192,569
Loss from operations	(148,435)	(177,720)	(174,757)
Interest and other income	5,127	62	9,420
Interest expense	(99,092)	(59,294)	(14,501)
Gain (loss) on extinguishment of debt	0	55,838	(2,011)
Foreign currency losses, net	(1,983)	(695)	(965)
Loss before income taxes	(244,383)	(181,809)	(182,814)
Income tax expense	2,733	2,253	0
Net loss	(247,116)	(184,062)	(182,814)
Foreign currency translation adjustment	890	189	0
Unrealized loss on available for sale investments	(1,041)	(15)	(36)
Net comprehensive loss	$ (247,267)	$ (183,888)	$ (182,850)
Earnings per share, basic (in usd per share)	$ (1.33)	$ (1.03)	$ (1.09)
Earnings per share, diluted (in usd per share)	$ (1.33)	$ (1.03)	$ (1.09)
Weighted average shares outstanding, basic (in shares)	185,908	179,117	167,267
Weighted average shares outstanding, diluted (in shares)	185,908	179,117	167,267
Product sales, net
Revenues
Total revenues	$ 267,710	$ 136,350	$ 3,301
Royalty revenue
Revenues
Total revenues	2,903	(100)	3,381
Milestone revenue
Revenues
Total revenues	0	15,000	0
Collaborative and other research and development
Revenues
Total revenues	$ 214	$ 5,920	$ 11,130