Note 8 - Royalty Monetizations Textual (Details) - USD ($)				12 Months Ended
	Nov. 19, 2021	Dec. 07, 2020	Mar. 09, 2011	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Dec. 01, 2020
Royalties Monetizations [Line Items]
Net proceeds from secured term loan				$ 0	$ 0	$ 119,867,000
Gain (loss) on extinguishment of debt				0	55,838,000	$ (2,011,000)
RPI 2019 Intermediate Finance Trust
Royalties Monetizations [Line Items]
Shares issued, common stock, premium				4,269,000
RPI 2019 Intermediate Finance Trust | ORLADEYO
Royalties Monetizations [Line Items]
Royalty purchase agreement, royalties, percentage of sublicense revenue in other markets		20.00%
RPI 2019 Intermediate Finance Trust | ORLADEYO | Annual Net Sales Under $350,000
Royalties Monetizations [Line Items]
Royalty purchase agreement, royalties, percentage of annual net sales in key territories		8.75%
RPI 2019 Intermediate Finance Trust | ORLADEYO | Annual Net Sales Between $350,000 and $550,000
Royalties Monetizations [Line Items]
Royalty purchase agreement, royalties, percentage of annual net sales in key territories		2.75%
RPI 2019 Intermediate Finance Trust | ORLADEYO | Annual Net Sales Over $550,000
Royalties Monetizations [Line Items]
Royalty purchase agreement, royalties, percentage of annual net sales in key territories		0.00%
RPI 2019 Intermediate Finance Trust | ORLADEYO | Annual Net Sales Under $150,000
Royalties Monetizations [Line Items]
Royalty purchase agreement, royalties, percentage of annual net sales in other markets		20.00%
RPI 2019 Intermediate Finance Trust | ORLADEYO | Annual Net Sales Between $150,000 and $230,000
Royalties Monetizations [Line Items]
Royalty purchase agreement, royalties, percentage of annual net sales in other markets		10.00%
RPI 2019 Intermediate Finance Trust | ORLADEYO | Annual Net Sales Over $230,000
Royalties Monetizations [Line Items]
Royalty purchase agreement, royalties, percentage of annual net sales in other markets		0.00%
RPI 2019 Intermediate Finance Trust | BCX9930
Royalties Monetizations [Line Items]
Royalty purchase agreement, royalties, percentage of global annual net sales		1.00%
Royalty purchase agreement, royalties, maximum tiered profit share percentage on permitted sales in other markets	3.00%
RPI 2019 Intermediate Finance Trust | BCX9930 | Annual Net Sales Over $3 Billions
Royalties Monetizations [Line Items]
Royalty purchase agreement, royalties, annual net sales payment threshold	$ 3,000,000,000
RPI 2019 Intermediate Finance Trust | Future Royalties Payable
Royalties Monetizations [Line Items]
Proceeds from issuance of debt		$ 125,000,000
Debt issuance costs, net, total				$ 8,532,000	8,497,000
RPI 2021 and 2020 Intermediate Finance Trust | Future Royalties Payable
Royalties Monetizations [Line Items]
Proceeds from issuance of debt	$ 150,000,000
The 2021 RPI Royalty Purchase Agreement | Annual Net Sales Under $350,000
Royalties Monetizations [Line Items]
Royalty purchase agreement, royalties, percentage of annual net sales in key territories	0.75%
The 2021 RPI Royalty Purchase Agreement | Annual Net Sales Between $350,000 and $550,000
Royalties Monetizations [Line Items]
Royalty purchase agreement, royalties, percentage of annual net sales in key territories	1.75%
Royalty purchase agreement, royalties, percentage of annual net sales in other markets	0.00%
The 2021 RPI Royalty Purchase Agreement | Annual Net Sales Under $150,000
Royalties Monetizations [Line Items]
Royalty purchase agreement, royalties, percentage of sublicense revenue in other markets	3.00%
The 2021 RPI Royalty Purchase Agreement | Annual Net Sales Between $150,000 and $230,000
Royalties Monetizations [Line Items]
Royalty purchase agreement, royalties, percentage of sublicense revenue in other markets	2.00%
The 2021 RPI Royalty Purchase Agreement | BCX9930 | Annual Net Sales Under $1.5 Million
Royalties Monetizations [Line Items]
Royalty purchase agreement, royalties, percentage of annual net sales in key territories	3.00%
The 2021 RPI Royalty Purchase Agreement | BCX9930 | Annual Net Sales Between $1.5 And $3 Million
Royalties Monetizations [Line Items]
Royalty purchase agreement, royalties, percentage of annual net sales in key territories	2.00%
The 2021 RPI Royalty Purchase Agreement | BCX9930 | Annual Net Sales Over $3 Billions
Royalties Monetizations [Line Items]
Royalty purchase agreement, royalties, percentage of annual net sales in other markets	0.00%
OMERS Capital Markets | ORLADEYO
Royalties Monetizations [Line Items]
Royalty purchase agreement, royalties, percentage of sublicense revenue in other markets	20.00%
Royalty purchase agreement, royalties, percentage of annual net sales in other markets	10.00%
Royalty purchase agreement, royalties, purchase price, amount	$ 150,000,000
OMERS Capital Markets | ORLADEYO | Minimum
Royalties Monetizations [Line Items]
Royalty purchase agreement, royalties, percentage of purchase price	142.50%
OMERS Capital Markets | ORLADEYO | Maximum
Royalties Monetizations [Line Items]
Royalty purchase agreement, royalties, percentage of purchase price	155.00%
OMERS Capital Markets | ORLADEYO | Annual Net Sales Under $350,000
Royalties Monetizations [Line Items]
Royalty purchase agreement, royalties, percentage of annual net sales	7.50%
Royalty purchase agreement, royalties, percentage of annual net sales, based on reduction in sales	10.00%
OMERS Capital Markets | ORLADEYO | Annual Net Sales Between $350,000 and $550,000
Royalties Monetizations [Line Items]
Royalty purchase agreement, royalties, percentage of annual net sales	6.00%
Royalty purchase agreement, royalties, percentage of annual net sales, based on reduction in sales	3.00%
OMERS Capital Markets | ORLADEYO | Annual Net Sales Over $550,000
Royalties Monetizations [Line Items]
Royalty purchase agreement, royalties, percentage of annual net sales	0.00%
Royalty purchase agreement, royalties, percentage of annual net sales, based on reduction in sales	0.00%
OMERS Capital Markets | ORLADEYO | Annual Net Sales Under $150,000
Royalties Monetizations [Line Items]
Royalty purchase agreement, royalties, percentage of sublicense revenue in other markets	20.00%
OMERS Capital Markets | ORLADEYO | Annual Net Sales Between $150,000 and $230,000
Royalties Monetizations [Line Items]
Royalty purchase agreement, royalties, percentage of sublicense revenue in other markets	10.00%
OMERS Capital Markets | ORLADEYO | Annual Net Sales Over $230,000
Royalties Monetizations [Line Items]
Royalty purchase agreement, royalties, percentage of sublicense revenue in other markets	0.00%
JPR Royalty Sub LLC | PhaRMA Notes
Royalties Monetizations [Line Items]
Private placement of senior secured notes			$ 30,000,000
Debt instrument, interest rate, stated percentage			14.00%
Secured debt, total							$ 30,000,000
Interest payable							$ 20,614,000
Gain (loss) on extinguishment of debt					25,838,000
JPR Royalty Sub LLC | PhaRMA Notes | Fair Value, Inputs, Level 2
Royalties Monetizations [Line Items]
Notes payable, fair value disclosure					$ 30,000,000
JPR Royalty Sub LLC | Royalty Monetization
Royalties Monetizations [Line Items]
Debt instrument, face amount			$ 30,000,000
Net proceeds from secured term loan			22,691,000
Transaction costs			4,309,000
Interest reserve			$ 3,000,000