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Cover Page - USD ($)
 12 Months Ended
Dec. 31, 2022
Jan. 31, 2023
Cover [Abstract]    
Document Type 10-K  
Document Annual Report true  
Document Period End Date Dec. 31, 2022  
Current Fiscal Year End Date --12-31  
Document Transition Report false  
Entity File Number 000-23186  
Entity Registrant Name BIOCRYST PHARMACEUTICALS, INC.  
Entity Incorporation, State or Country Code DE  
Entity Tax Identification Number 62-1413174  
Entity Address, Address Line One 4505 Emperor Blvd., Suite 200  
Entity Address, City or Town Durham  
Entity Address, State or Province NC  
Entity Address, Postal Zip Code 27703  
City Area Code 919  
Local Phone Number 859-1302  
Title of 12(b) Security Common Stock, $0.01 par value  
Trading Symbol BCRX  
Security Exchange Name NASDAQ  
Entity Well-known Seasoned Issuer Yes  
Entity Voluntary Filers No  
Entity Current Reporting Status Yes  
Entity Interactive Data Current Yes  
Entity Filer Category Large Accelerated Filer  
Entity Small Business false  
Entity Emerging Growth Company false  
ICFR Auditor Attestation Flag true  
Entity Shell Company false  
Entity Public Float $ 1,949,284,603  
Entity Common Stock, Shares Outstanding   188,451,137
Documents Incorporated by Reference
DOCUMENTS INCORPORATED BY REFERENCE
Portions of the registrant’s definitive proxy statement to be filed in connection with the solicitation of proxies for its 2023 annual meeting of stockholders are incorporated by reference into Items 10, 11, 12, 13, and 14 under Part III hereof.
  
Entity Central Index Key 0000882796  
Document Fiscal Year Focus 2022  
Document Fiscal Period Focus FY  
Amendment Flag false