Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021
Cash flows from operating activities:
Net loss	$ (175,575)	$ (166,283)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	1,041	606
Stock-based compensation expense	29,419	26,140
Non-cash interest expense on royalty financing obligations and secured term loan and amortization of debt issuance costs	55,119	36,440
Amortization of premium/discount on investments	(818)	35
Changes in operating assets and liabilities:
Receivables	(13,827)	(17,579)
Inventory	(11,263)	(6,630)
Prepaid expenses and other assets	(1,132)	(3,460)
Accounts payable and accrued expenses	(27,639)	16,692
Interest payable	6,345	3,884
Deferred revenue	329	457
Net cash used in operating activities	(138,001)	(109,698)
Cash flows from investing activities:
Acquisitions of property and equipment	(825)	(1,277)
Purchase of investments	(244,283)	0
Sales and maturities of investments	39,655	28,201
Net cash (used in) provided by investing activities	(205,453)	26,924
Cash flows from financing activities:
Net proceeds from common stock issued under stock-based compensation plans	10,756	12,250
Net proceeds from secured term loans	73,072	0
Net cash provided by financing activities	83,828	12,250
Effect of exchange rate on cash, cash equivalents, and restricted cash	235	69
Decrease in cash, cash equivalents and restricted cash	(259,391)	(70,455)
Cash, cash equivalents and restricted cash at beginning of period	507,734	274,348
Cash, cash equivalents and restricted cash at end of period	$ 248,343	$ 203,893