Consolidated Statements of Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Revenues
Total revenues	$ 75,827	$ 40,994	$ 191,282	$ 110,012
Expenses
Cost of product sales	3,543	591	4,025	6,811
Research and development	52,740	49,971	180,090	145,279
Selling, general and administrative	36,919	34,992	109,218	83,431
Royalty	70	24	73	34
Total operating expenses	93,272	85,578	293,406	235,555
Loss from operations	(17,445)	(44,584)	(102,124)	(125,543)
Interest and other income	1,760	9	2,423	48
Interest expense	(24,775)	(14,115)	(72,634)	(40,514)
Foreign currency losses, net	(538)	(111)	(583)	(274)
Loss before income taxes	(40,998)	(58,801)	(172,918)	(166,283)
Income tax expense	1,522	0	2,657	0
Net loss	(42,520)	(58,801)	(175,575)	(166,283)
Foreign currency translation adjustment	695	28	877	114
Unrealized loss on available for sale investments	(808)	(1)	(1,152)	(3)
Comprehensive loss	$ (42,633)	$ (58,774)	$ (175,850)	$ (166,172)
Basic net loss per common share (in usd per share)	$ (0.23)	$ (0.33)	$ (0.95)	$ (0.93)
Diluted net loss per common share (in usd per share)	$ (0.23)	$ (0.33)	$ (0.95)	$ (0.93)
Weighted average shares outstanding, basic (in shares)	186,180	179,106	185,566	178,199
Weighted average shares outstanding, diluted (in shares)	186,180	179,106	185,566	178,199
Product sales, net
Revenues
Total revenues	$ 75,213	$ 39,141	$ 189,647	$ 90,442
Royalty revenue
Revenues
Total revenues	600	322	1,487	(447)
Milestone revenue
Revenues
Total revenues	0	0	0	15,000
Collaborative and other research and development
Revenues
Total revenues	$ 14	$ 1,531	$ 148	$ 5,017