Consolidated Statements of Comprehensive Loss (USD $) In Thousands, except Per Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Revenues
Royalty revenue	$ 2,562	$ 3,317
Collaborative and other research and development	14,769	22,976	19,643
Total revenues	17,331	26,293	19,643
Expenses
Research and development	42,730	51,464	57,249
General and administrative	5,220	6,826	11,981
Royalty	98	132
Restructuring		1,759
Total operating expenses	48,048	60,181	69,230
Loss from operations	(30,717)	(33,888)	(49,587)
Interest and other income	93	222	413
Interest expense	(4,778)	(4,666)	(3,774)
Gain (loss) on foreign currency derivative	5,294	(749)	(4,000)
Net loss	(30,108)	(39,081)	(56,948)
Basic and diluted net loss per common share	$ (0.55)	$ (0.79)	$ (1.26)
Weighted average shares outstanding	55,216	49,474	45,144
Unrealized loss on available for sale investments	(23)	(13)	(65)
Comprehensive loss	$ (30,131)	$ (39,094)	$ (57,013)