Consolidated Statements of Comprehensive Loss (Unaudited) (USD $) In Thousands, except Per Share data, unless otherwise specified	3 Months Ended		6 Months Ended
	Jun. 30, 2013	Jun. 30, 2012	Jun. 30, 2013	Jun. 30, 2012
Revenues
Royalty revenue	$ 110		$ 2,034
Collaborative and other research and development	711	4,210	2,341	16,431
Total revenues	821	4,210	4,375	16,431
Expenses
Research and development	11,728	12,777	19,139	28,302
General and administrative	1,231	1,609	2,613	3,306
Royalty	4		81
Total operating expenses	12,963	14,386	21,833	31,608
Loss from operations	(12,142)	(10,176)	(17,458)	(15,177)
Interest and other income	21	57	54	128
Interest expense	(1,165)	(1,160)	(2,345)	(2,320)
Gain (loss) on foreign currency derivative	1,114	(997)	3,071	(959)
Net loss	(12,172)	(12,276)	(16,678)	(18,328)
Basic and diluted net loss per common share	$ (0.23)	$ (0.25)	$ (0.32)	$ (0.38)
Weighted average shares outstanding	53,468	49,218	52,277	48,161
Unrealized loss on investments	(9)	(9)	(21)
Comprehensive loss	$ (12,181)	$ (12,285)	$ (16,699)	$ (18,328)