Note 8 - Royalty Monetizations - Schedule of Royalty Financing Obligations (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Royalty financing obligation, net of issuance costs	$ 298,142	$ 122,609
Non-cash Interest expense on Royalty financing obligation	37,670	2,108
Balance	124,717
Royalty revenues paid and payable	(11,154)
Balance	449,375	124,717
2020 RPI Royalty Agreement [Member]
Royalty financing obligation, net of issuance costs		122,609
Non-cash Interest expense on Royalty financing obligation	33,308	2,108
Balance	124,717
Royalty revenues paid and payable	(10,801)
Balance	$ 147,224	$ 124,717
Effective interest rate	27.30%
2021 RPI Royalty Agreement [Member]
Royalty financing obligation, net of issuance costs	$ 150,833
Non-cash Interest expense on Royalty financing obligation	2,897
Royalty revenues paid and payable	(353)
Balance	$ 153,377
Effective interest rate	16.50%
OMERS Royalty Agreement [Member]
Royalty financing obligation, net of issuance costs	$ 147,309
Non-cash Interest expense on Royalty financing obligation	1,465
Balance	$ 148,774
Effective interest rate	8.50%