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Note 8 - Royalty Monetizations (Details Textual) - USD ($) $ in Thousands				12 Months Ended
	Nov. 19, 2021	Dec. 07, 2020	Mar. 09, 2011	Dec. 31, 2021	Dec. 31, 2020	Jun. 30, 2021	Dec. 01, 2020
Proceeds from Issuance of Secured Debt					$ 119,867
Gain (Loss) on Extinguishment of Debt, Total				$ 55,838	$ (2,011)
RPI 2019 Intermediate Finance Trust [Member]
Shares Issued, Common Stock, Premium				4,269
RPI 2019 Intermediate Finance Trust [Member] \| ORLADEYO [Member]
Royalty Purchase Agreement, Royalties, Percentage of Sublicense Revenue in Other Markets		20.00%
RPI 2019 Intermediate Finance Trust [Member] \| ORLADEYO [Member] \| Annual Net Sales Under $350,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Key Territories		8.75%
RPI 2019 Intermediate Finance Trust [Member] \| ORLADEYO [Member] \| Annual Net Sales Between $350,000 and $550,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Key Territories		2.75%
RPI 2019 Intermediate Finance Trust [Member] \| ORLADEYO [Member] \| Annual Net Sales Over $550,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Key Territories		0.00%
RPI 2019 Intermediate Finance Trust [Member] \| ORLADEYO [Member] \| Annual Net Sales Under $150,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Other Markets		20.00%
RPI 2019 Intermediate Finance Trust [Member] \| ORLADEYO [Member] \| Annual Net Sales Between $150,000 and $230,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Other Markets		10.00%
RPI 2019 Intermediate Finance Trust [Member] \| ORLADEYO [Member] \| Annual Net Sales Over $230,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Other Markets		0.00%
RPI 2019 Intermediate Finance Trust [Member] \| BCX9930 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Global Annual Net Sales		1.00%
Royalty Purchase Agreement, Royalties, Maximum Tiered Profit Share Percentage on Permitted Sales in Other Markets	3.00%
RPI 2019 Intermediate Finance Trust [Member] \| BCX9930 [Member] \| Annual Net Sales Over $3 Billions [Member]
Royalty Purchase Agreement, Royalties, Annual Net Sales Payment Threshold	$ 3,000,000
RPI 2019 Intermediate Finance Trust [Member] \| Future Royalties Payable [Member]
Proceeds from Issuance of Debt		$ 125,000
Debt Issuance Costs, Net, Total				2,370
RPI 2021 and 2020 Intermediate Finance Trust [Member] \| Future Royalties Payable [Member]
Proceeds from Issuance of Debt	$ 150,000
The 2021 RPI Royalty Purchase Agreement [Member] \| Annual Net Sales Under $350,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Key Territories	0.75%
The 2021 RPI Royalty Purchase Agreement [Member] \| Annual Net Sales Between $350,000 and $550,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Key Territories	1.75%
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Other Markets	0.00%
The 2021 RPI Royalty Purchase Agreement [Member] \| Annual Net Sales Under $150,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Sublicense Revenue in Other Markets	3.00%
The 2021 RPI Royalty Purchase Agreement [Member] \| Annual Net Sales Between $150,000 and $230,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Sublicense Revenue in Other Markets	2.00%
The 2021 RPI Royalty Purchase Agreement [Member] \| BCX9930 [Member] \| Annual Net Sales Under $1.5 Billion [Member]
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Key Territories	3.00%
The 2021 RPI Royalty Purchase Agreement [Member] \| BCX9930 [Member] \| Annual Net Sales Between $1.5 and $3 Billions [Member]
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Key Territories	2.00%
The 2021 RPI Royalty Purchase Agreement [Member] \| BCX9930 [Member] \| Annual Net Sales Over $3 Billions [Member]
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Other Markets	0.00%
OMERS Capital Markets [Member] \| ORLADEYO [Member]
Royalty Purchase Agreement, Royalties, Percentage of Sublicense Revenue in Other Markets	20.00%
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Other Markets	10.00%
Royalty Purchase Agreement, Royalties, Purchase Price, Amount	$ 150,000
OMERS Capital Markets [Member] \| ORLADEYO [Member] \| Minimum [Member]
Royalty Purchase Agreement, Royalties, Percentage of Purchase Price	142.50%
OMERS Capital Markets [Member] \| ORLADEYO [Member] \| Maximum [Member]
Royalty Purchase Agreement, Royalties, Percentage of Purchase Price	155.00%
OMERS Capital Markets [Member] \| ORLADEYO [Member] \| Annual Net Sales Under $350,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales	7.50%
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales, Based on Reduction in Sales	10.00%
OMERS Capital Markets [Member] \| ORLADEYO [Member] \| Annual Net Sales Between $350,000 and $550,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales	6.00%
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales, Based on Reduction in Sales	3.00%
OMERS Capital Markets [Member] \| ORLADEYO [Member] \| Annual Net Sales Over $550,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales	0.00%
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales, Based on Reduction in Sales	0.00%
OMERS Capital Markets [Member] \| ORLADEYO [Member] \| Annual Net Sales Under $150,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Sublicense Revenue in Other Markets	20.00%
OMERS Capital Markets [Member] \| ORLADEYO [Member] \| Annual Net Sales Between $150,000 and $230,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Sublicense Revenue in Other Markets	10.00%
OMERS Capital Markets [Member] \| ORLADEYO [Member] \| Annual Net Sales Over $230,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Sublicense Revenue in Other Markets	0.00%
JPR Royalty Sub LLC [Member] \| PhaRMA Notes Member]
Private Placement of Senior Secured Notes			$ 30,000
Debt Instrument, Interest Rate, Stated Percentage			14.00%
Secured Debt, Total							$ 30,000
Interest Payable							$ 20,614
Gain (Loss) on Extinguishment of Debt, Total				$ 25,838
JPR Royalty Sub LLC [Member] \| PhaRMA Notes Member] \| Fair Value, Inputs, Level 2 [Member]
Notes Payable, Fair Value Disclosure						$ 30,000
JPR Royalty Sub LLC [Member] \| Royalty Monetization [Member]
Debt Instrument, Face Amount			$ 30,000
Proceeds from Issuance of Secured Debt			22,691
Transaction Costs			4,309
Interest Reserve			$ 3,000