Consolidated Statements of Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Revenues:
Revenues	$ 157,170	$ 17,812	$ 48,835
Expenses
Cost of products sold	7,229	1,550	3,726
Research and development	208,808	122,964	107,068
Selling, general and administrative	118,818	67,929	37,121
Royalty	35	126	375
Total operating expenses	334,890	192,569	148,290
Loss from operations	(177,720)	(174,757)	(99,455)
Interest and other income	62	9,420	1,933
Interest expense	(59,294)	(14,501)	(11,892)
Gain (loss) on extinguishment of debt	55,838	(2,011)
Foreign currency (losses) gains, net	(695)	(965)	517
Loss before income taxes	(181,809)	(182,814)	(108,897)
Income tax expense	2,253	0	0
Net loss	(184,062)	(182,814)	(108,897)
Foreign currency translation adjustment	189
Unrealized (loss) gain on available for sale investments	(15)	(36)	336
Net comprehensive loss	$ (183,888)	$ (182,850)	$ (108,561)
Basic and diluted net loss per common share (in dollars per share)	$ (1,030.00)	$ (1,090.00)	$ (940)
Weighted average shares outstanding (in shares)	179,117	167,267	115,600
Product [Member]
Revenues:
Revenues	$ 136,350	$ 3,301	$ 17,533
Royalty [Member]
Revenues:
Revenues	(100)	3,381	6,303
Milestone [Member]
Revenues:
Revenues	15,000
Collaborative and Other Research and Development [Member]
Revenues:
Revenues	$ 5,920	$ 11,130	$ 24,999