The amount of amortization of debt financing costs and original issue discounts.

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Average maturity period of high quality marketable securities.

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Represents long term investment maturity minimum.

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Maturity period of short term investment.

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Amount charged to advertising expense for the period, which are expenses incurred with the objective of increasing revenue for a specified brand, product or product line.

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Securities (including those issuable pursuant to contingent stock agreements) that could potentially dilute basic earnings per share (EPS) or earnings per unit (EPU) in the future that were not included in the computation of diluted EPS or EPU because to do so would increase EPS or EPU amounts or decrease loss per share or unit amounts for the period presented.

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Amount of increase in the fair value of derivatives recognized in the income statement.

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Amount of decrease in the fair value of derivatives recognized in the income statement.

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Amount of the cost of borrowed funds accounted for as interest expense for debt.

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Amount of borrowing capacity currently available under the credit facility (current borrowing capacity less the amount of borrowings outstanding).

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Amount of cash inflow (outflow) from financing activities, including discontinued operations. Financing activity cash flows include obtaining resources from owners and providing them with a return on, and a return of, their investment; borrowing money and repaying amounts borrowed, or settling the obligation; and obtaining and paying for other resources obtained from creditors on long-term credit.

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Amount of cash inflow (outflow) from operating activities, including discontinued operations. Operating activity cash flows include transactions, adjustments, and changes in value not defined as investing or financing activities.

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Useful life of long lived, physical assets used in the normal conduct of business and not intended for resale, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. Examples include, but not limited to, land, buildings, machinery and equipment, office equipment, furniture and fixtures, and computer equipment.

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Amount before tax of reclassification adjustments of other comprehensive income (loss).

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Amount of cash and cash equivalents restricted as to withdrawal or usage, classified as current. Cash includes, but is not limited to, currency on hand, demand deposits with banks or financial institutions, and other accounts with general characteristics of demand deposits. Cash equivalents include, but are not limited to, short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates.

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Write-off of amounts previously capitalized as debt issuance cost in an extinguishment of debt.

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Note 1 - Significant Accounting Policies and Concentrations of Risk (Details Textual) - USD ($) $ in Thousands	1 Months Ended	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Net Cash Provided by (Used in) Operating Activities, Total		$ (142,157)	$ (135,108)	$ (89,584)
Net Cash Provided by (Used in) Financing Activities, Total		359,668	300,589	99,098
Restricted Cash and Cash Equivalents, Current, Total	$ 2,221	3,345	2,221
Advertising Expense		5,705	6,567	0
Interest Expense, Debt, Total		59,294	14,501	11,892
Amortization of Debt Financing Costs and Original Issue Discounts		$ 531	$ 1,217	$ 1,278
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount (in shares)		26,034	14,957	2,805
Reclassification from Accumulated Other Comprehensive Income, Current Period, before Tax		$ 1	$ 1
Foreign Exchange Contract [Member] \| Not Designated as Hedging Instrument [Member]
Derivative, Loss on Derivative			632	$ 347
Derivative, Gain on Derivative			662	$ 863
Computer Equipment [Member]
Property, Plant and Equipment, Useful Life (Year)		3 years
Laboratory Equipment, Office Equipment and Software [Member]
Property, Plant and Equipment, Useful Life (Year)		5 years
Furniture and Fixtures [Member]
Property, Plant and Equipment, Useful Life (Year)		7 years
Royalty Receivable [Member]
Restricted Cash and Cash Equivalents, Current, Total	796	$ 1,924	796
Collateral for Credit [Member]
Restricted Cash and Cash Equivalents, Current, Total	1,425	$ 1,421	1,425
Maximum [Member]
Maturity Period of High Quality Marketable Securities (Year)		3 years
Average Maturity Period of High Quality Marketable Securities (Month)		12 months
Maturity Period of Short Term Investment (Month)		12 months
Minimum [Member]
Long-term Investment Maturity, Minimum (Year)		12 years
Previously Reported [Member]
Net Cash Provided by (Used in) Operating Activities, Total			(137,216)
Net Cash Provided by (Used in) Financing Activities, Total			302,697
Senior Credit Facility [Member] \| MidCap Financial Services, LLC [Member]
Line of Credit Facility, Remaining Borrowing Capacity		$ 75,000
Write off of Deferred Debt Issuance Cost	$ 1,211		$ 1,211