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Note 2 - Revenue (Tables)
12 Months Ended
Dec. 31, 2021
Notes Tables  
Disaggregation of Revenue [Table Text Block]
  

2021

  

2020

  

2019

 

Product sales, net:

            

ORLADEYO

 $121,865  $133  $ 

RAPIVAB

  7,231   483   13,864 

Peramivir

  7,254   2,685   3,669 

Total product sales, net

  136,350   3,301   17,533 

Royalty revenue

  (100)  3,381   6,303 

Milestone revenue

  15,000       

Collaborative and other research and development revenues:

            

U.S. Department of Health and Human Services

  5,920   9,231   4,898 

Torii Pharmaceutical Co., Ltd.

     1,899   20,101 

Total collaborative and other research and development revenues

  5,920   11,130   24,999 

Total revenues

 $157,170  $17,812  $48,835