Consolidated Statements of Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Revenues:
Revenues	$ 17,812	$ 48,835	$ 20,653
Expenses
Cost of products sold	1,550	3,726
Research and development	122,964	107,068	84,888
Selling, general and administrative	67,929	37,121	29,514
Royalty	126	375	471
Total operating expenses	192,569	148,290	114,873
Loss from operations	(174,757)	(99,455)	(94,220)
Interest and other income	9,420	1,933	2,252
Interest expense	(14,501)	(11,892)	(9,176)
Loss on extinguishment of debt	(2,011)
Gain (loss) on foreign currency	(965)	517	(108)
Net loss	(182,814)	(108,897)	(101,252)
Unrealized gain (loss) on available for sale investments	(36)	336	(54)
Net comprehensive loss	$ (182,850)	$ (108,561)	$ (101,306)
Basic and diluted net loss per common share (in dollars per share)	$ (1.09)	$ (0.94)	$ (0.98)
Weighted average shares outstanding (in shares)	167,267	115,600	103,185
Product [Member]
Revenues:
Revenues	$ 3,301	$ 17,533
Royalty [Member]
Revenues:
Revenues	3,381	6,303	$ 6,101
Collaborative and Other Research and Development [Member]
Revenues:
Revenues	$ 11,130	$ 24,999	$ 14,552