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Note 4 - Credit Agreement (Details Textual) - USD ($)
$ in Thousands
12 Months Ended
Dec. 07, 2020
Feb. 05, 2019
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Repayments of Lines of Credit     $ 52,420   $ 4,025
Interest Expense, Debt, Total     14,501 $ 11,892 9,176
Amortization of Debt Issuance Costs     2,428 $ 1,278 $ 885
MidCap Financial Services, LLC [Member] | Senior Credit Facility [Member]          
Debt Instrument, Face Amount   $ 100,000      
Repayments of Lines of Credit $ 43,298        
MidCap Financial Services, LLC [Member] | Senior Credit Facility [Member] | London Interbank Offered Rate (LIBOR) [Member]          
Debt Instrument, Basis Spread on Variable Rate   8.00%      
Credit Agreement [Member] | Athyrium [Member]          
Debt Instrument, Face Amount $ 200,000        
Debt Instrument, LIBOR Floor 1.75%        
Debt Instrument, LIBOR Cap 3.50%        
Debt Instrument, Exit Fee, Percentage of Principal 2.00%        
Debt Instrument, Commitment Fee Percentage 1.00%        
Long-term Debt, Total     $ 125,000    
Debt Instrument, Interest Rate, Effective Percentage     12.17%    
Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net, Total     $ 7,764    
Credit Agreement [Member] | Athyrium [Member] | Prior to the Second Anniversary [Member]          
Debt Instrument, Prepayment Fee, Percentage of Principal Voluntary Payments 102.00%        
Debt Instrument, Prepayment Fee, Percentage of Accrued Interest 0.50%        
Credit Agreement [Member] | Athyrium [Member] | Between the Second and Third Anniversaries [Member]          
Debt Instrument, Prepayment Fee, Percentage of Principal Voluntary Payments 2.00%        
Credit Agreement [Member] | Athyrium [Member] | Between the Third and Fourth Anniversaries [Member]          
Debt Instrument, Prepayment Fee, Percentage of Principal Voluntary Payments 1.00%        
Credit Agreement [Member] | Athyrium [Member] | After Fourth Anniversary [Member]          
Debt Instrument, Prepayment Fee, Percentage of Principal Voluntary Payments 0.00%        
Credit Agreement [Member] | Athyrium [Member] | Term Loan A Drawn [Member]          
Debt Instrument, Covenant, Minimum Unrestricted Cash and Cash Equivalents $ 15,000        
Credit Agreement [Member] | Athyrium [Member] | Term Loan A and B Drawn [Member]          
Debt Instrument, Covenant, Minimum Unrestricted Cash and Cash Equivalents 20,000        
Credit Agreement [Member] | Athyrium [Member] | Term Loans A, B and C Drawn [Member]          
Debt Instrument, Covenant, Minimum Unrestricted Cash and Cash Equivalents 15,000        
Credit Agreement [Member] | Athyrium [Member] | Term Loans A, B and C Drawn and Cure Right Exercised [Member]          
Debt Instrument, Covenant, Minimum Unrestricted Cash and Cash Equivalents $ 20,000        
Credit Agreement [Member] | Athyrium [Member] | London Interbank Offered Rate (LIBOR) [Member]          
Debt Instrument, Basis Spread on Variable Rate 8.25%        
Credit Agreement [Member] | Athyrium [Member] | London Interbank Offered Rate (LIBOR) [Member] | PIK Interest Payment is Made [Member]          
Debt Instrument, Basis Spread on Variable Rate 10.25%        
Credit Agreement [Member] | Athyrium [Member] | Term A Loan [Member]          
Proceeds from Issuance of Long-term Debt, Total $ 125,000        
Interest Expense, Debt, Total     925    
Amortization of Debt Issuance Costs     $ 131    
Credit Agreement [Member] | Athyrium [Member] | Term B Loan [Member]          
Debt Instrument, Face Amount 25,000        
Credit Agreement [Member] | Athyrium [Member] | Term C Loan [Member]          
Debt Instrument, Face Amount $ 50,000