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Note 2 - Property and Equipment (Tables)
 12 Months Ended
Dec. 31, 2019
Notes Tables  
Property, Plant and Equipment [Table Text Block]
    2019   2018
Furniture and fixtures   $
602
     $
573
  
Office equipment    
184
      
152
  
Software    
1,159
      
1,125
  
Laboratory equipment    
3,462
      
3,329
  
Leased equipment    
-
      
143
  
Leasehold improvements    
8,528
      
8,413
  
Building    
-
      
1,495
  
     
13,935
      
15,230
  
Less accumulated depreciation and amortization    
(6,588
 )    
(6,095
 )
Property and equipment, net   $
7,347
     $
9,135