Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Revenues:
Revenues	$ 1,775	$ 1,454	$ 9,110	$ 17,924
Expenses
Cost of product sales			1,399
Research and development	25,120	22,006	80,294	61,457
Selling, general and administrative	11,735	7,923	26,632	25,024
Royalty	18	18	131	401
Total operating expenses	36,873	29,947	108,456	86,882
Loss from operations	(35,098)	(28,493)	(99,346)	(68,958)
Interest and other income	402	611	1,545	1,566
Interest expense	(3,044)	(2,346)	(8,805)	(6,762)
Gain on foreign currency derivative	148	631	331	334
Net loss	(37,592)	(29,597)	(106,275)	(73,820)
Unrealized gain (loss) on available for sale investments	19	42	357	(167)
Comprehensive loss	$ (37,573)	$ (29,555)	$ (105,918)	$ (73,987)
Basic and diluted net loss per common share (in dollars per share)	$ (0.34)	$ (0.28)	$ (0.96)	$ (0.73)
Weighted average shares outstanding (in shares)	110,416	105,410	110,308	100,955
Product [Member]
Revenues:
Revenues	$ 335		$ 2,014
Royalty [Member]
Revenues:
Revenues	508	523	3,526	4,326
Collaborative and Other Research and Development [Member]
Revenues:
Revenues	$ 932	$ 931	$ 3,570	$ 13,598