Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018
Revenues:
Revenues	$ 5,887	$ 3,976
Expenses
Cost of product sales	1,399
Research and development	27,493	18,441
General and administrative	6,238	7,609
Royalty	87	140
Total operating expenses	35,217	26,190
Loss from operations	(29,330)	(22,214)
Interest and other income	596	462
Interest expense	(2,726)	(2,221)
Gain (loss) on foreign currency derivative	406	(1,804)
Net loss	(31,054)	(25,777)
Unrealized gain (loss) on available for sale investments	208	(233)
Net comprehensive loss	$ (30,846)	$ (26,010)
Basic and diluted net loss per common share (in dollars per share)	$ (0.28)	$ (0.26)
Weighted average shares outstanding (in shares)	110,167	98,592
Product [Member]
Revenues:
Revenues	$ 1,679
Royalty [Member]
Revenues:
Revenues	2,322	3,661
Collaborative and Other Research and Development [Member]
Revenues:
Revenues	$ 1,886	$ 315