Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2017	Sep. 30, 2016	Sep. 30, 2017	Sep. 30, 2016
Revenues
Product sales	$ 1,501		$ 1,501
Royalty revenue	442	3,501	7,252	6,020
Collaborative and other research and development	6,817	4,262	12,543	11,350
Total revenues	8,760	7,763	21,296	17,370
Expenses
Cost of products sold	1,142		1,142
Research and development	17,509	14,105	50,038	48,850
General and administrative	3,343	2,756	9,235	8,692
Royalty	115	143	431	247
Total operating expenses	22,109	17,004	60,846	57,789
Loss from operations	(13,349)	(9,241)	(39,550)	(40,419)
Interest and other income	225	109	537	695
Interest expense	(2,140)	(1,465)	(6,334)	(4,356)
Gain (loss) on foreign currency derivative	130	(931)	(892)	(6,561)
Net loss	$ (15,134)	$ (11,528)	$ (46,239)	$ (50,641)
Basic and diluted net loss per common share (in dollars per share)	$ (0.18)	$ (0.16)	$ (0.58)	$ (0.69)
Weighted average shares outstanding (in shares)	83,570	73,734	79,749	73,677
Unrealized loss on available for sale investments	$ (2)	$ (24)	$ (5)	$ 228
Comprehensive loss	$ (15,136)	$ (11,552)	$ (46,244)	$ (50,413)