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Note 1 - Significant Accounting Policies and Concentrations of Risk (Details Textual) - USD ($) shares in Thousands		1 Months Ended	12 Months Ended
	Nov. 06, 2013	Jun. 30, 2015	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013	Mar. 09, 2011
Currency Hedge Agreement [Member]
Collateral Already Posted, Aggregate Fair Value			$ 0	$ 0
Foreign Exchange Contract [Member] \| Not Designated as Hedging Instrument [Member]
Derivative, Loss on Derivative			564,000
Derivative, Gain on Derivative			$ 1,654,000	5,487,000	$ 5,294,000
JPR Royalty Sub LLC [Member]
Revenue Recognition Royalty and Milestone Revenue Recognized						$ 30,000,000
Maximum [Member]
Maturity of Investments			3 years
Maturity Period of High Quality Marketable Securities			3 years
Average Maturity Period of High Quality Marketable Securities			1 year 180 days
Maturity Period of Short Term Investment			1 year
Average Maturity for Portfolio Investments			1 year 180 days
Minimum [Member]
Maturity Period of Short Term Investment			90 days
Long-term Investment Maturity, Minimum			1 year
Certificates of Deposit [Member]
Restricted Cash and Cash Equivalents, Current			$ 150,000
Royalty Receivable [Member]
Restricted Cash and Cash Equivalents, Current			59,000
Collateral for Credit [Member]
Restricted Cash and Cash Equivalents			$ 1,403,000
Computer Equipment [Member]
Property, Plant and Equipment, Useful Life			3 years
Laboratory Equipment, Office Equipment and Software [Member]
Property, Plant and Equipment, Useful Life			5 years
Furniture and Fixtures [Member]
Property, Plant and Equipment, Useful Life			7 years
Building [Member]
Property, Plant and Equipment, Useful Life			10 years
Agreement [Member] \| CSL [Member] \| RAPIVABMember \| Contingent upon EU Marketing Approval [Member]
Proceeds from License Fees Received		$ 7,000,000
Agreement [Member] \| CSL [Member] \| RAPIVABMember \| Revenue from Sale of Inventory to be Recognized When the Inventory Transfer Is Complete [Member]
Deferred Revenue, Additions		3,740,000
Agreement [Member] \| CSL [Member] \| RAPIVABMember \| Regulatory Support Revenue for Canadian and EU Marketing Approvals, Portion Recognized Ratably Over Expected Period of Involvement [Member]
Deferred Revenue, Additions		1,223,000
Agreement [Member] \| CSL [Member] \| RAPIVABMember
Proceeds from License Fees Received		33,740,000
Revenues		21,777,000
Milestone Payment Maximum		$ 12,000,000
RAPIVABMember \| Customer Concentration Risk [Member] \| Sales Revenue, Product Line [Member]
Concentration Risk, Percentage			90.00%
PhaRMA Notes Member]
Interest Expense			$ 5,200,000	4,998,000	4,778,000
Reclassification from Accumulated Other Comprehensive Income, Current Period, before Tax			13,000	0
Amortization of Financing Costs			439,000	439,000	439,000
Investments and Cash			100,858,000
Securities Offered	$ 10,000,000
Restricted Cash and Cash Equivalents, Current			1,612,000	150,000
Revenues			48,257,000	13,608,000	17,331,000
Advertising Expense			103,000	290,000
Interest Expense			$ 5,200,000	$ 4,998,000	$ 4,778,000
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount			3,524	3,991	1,430