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Note 2 - Furniture and Equipment (Tables)
12 Months Ended
Dec. 31, 2014
Property, Plant and Equipment [Abstract]  
Property, Plant and Equipment [Table Text Block]
    2014   2013
Furniture and fixtures   $ 542     $ 600  
Office equipment     1,115       1,266  
Software     1,423       1,448  
Laboratory equipment     5,786       5,721  
Leased equipment     63       63  
Leasehold improvements     5,303       5,316  
      14,232       14,414  
Less accumulated depreciation and amortization     (14,025 )     (14,108 )
Furniture and equipment, net   $ 207     $ 306