<SEC-DOCUMENT>0001144204-16-087822-index.html : 20160314
<SEC-HEADER>0001144204-16-087822.hdr.sgml : 20160314
<ACCEPTANCE-DATETIME>20160314160219
ACCESSION NUMBER:		0001144204-16-087822
CONFORMED SUBMISSION TYPE:	SC 13G
PUBLIC DOCUMENT COUNT:		3
FILED AS OF DATE:		20160314
DATE AS OF CHANGE:		20160314
GROUP MEMBERS:		DAVID E. SHAW

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BIOCRYST PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000882796
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				621413174
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-44055
		FILM NUMBER:		161503841

	BUSINESS ADDRESS:	
		STREET 1:		4505 EMPEROR BOULEVARD
		STREET 2:		SUITE 200
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27703
		BUSINESS PHONE:		919-859-1302

	MAIL ADDRESS:	
		STREET 1:		4505 EMPEROR BOULEVARD
		STREET 2:		SUITE 200
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27703

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			D. E. SHAW & CO, L.P.
		CENTRAL INDEX KEY:			0001009268
		IRS NUMBER:				133695715
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G

	BUSINESS ADDRESS:	
		STREET 1:		1166 AVENUE OF THE AMERICAS
		STREET 2:		NINTH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10036
		BUSINESS PHONE:		2124780000

	MAIL ADDRESS:	
		STREET 1:		1166 AVENUE OF THE AMERICAS
		STREET 2:		NINTH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10036

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SHAW D E & CO L P /NY/
		DATE OF NAME CHANGE:	19990421
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G
<SEQUENCE>1
<FILENAME>v434099_sc13g.htm
<DESCRIPTION>SCHEDULE 13G
<TEXT>
Document 1 - file: v434099_sc13g.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>v434099_ex1.htm
<DESCRIPTION>EXHIBIT 1
<TEXT>
Document 2 - file: v434099_ex1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.2
<SEQUENCE>3
<FILENAME>v434099_ex2.htm
<DESCRIPTION>EXHIBIT 2
<TEXT>
Document 3 - file: v434099_ex2.htm

</DOCUMENT>
</SEC-DOCUMENT>