Organization and Summary of Significant Accounting Policies (Details) $ in Millions	12 Months Ended
	Dec. 31, 2022 USD ($) segment country	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)
Organization And Summary Of Significant Accounting Policies [Line Items]
Number of countries in which entity operates | country	35
Number of operating segments | segment	1
Decrease in research and development	$ (4,977)	$ (4,601)	$ (4,927)
Advertising expense	$ 778	735	795
Revision of Prior Period, Reclassification, Adjustment
Organization And Summary Of Significant Accounting Policies [Line Items]
Decrease in research and development		$ 762	$ 112
Buildings and improvements
Organization And Summary Of Significant Accounting Policies [Line Items]
Property, plant and equipment, useful life	35 years
Minimum | Laboratory and manufacturing equipment
Organization And Summary Of Significant Accounting Policies [Line Items]
Property, plant and equipment, useful life	4 years
Minimum | Office, computer equipment and other
Organization And Summary Of Significant Accounting Policies [Line Items]
Property, plant and equipment, useful life	3 years
Maximum | Laboratory and manufacturing equipment
Organization And Summary Of Significant Accounting Policies [Line Items]
Property, plant and equipment, useful life	10 years
Maximum | Office, computer equipment and other
Organization And Summary Of Significant Accounting Policies [Line Items]
Property, plant and equipment, useful life	15 years