CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Millions	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Operating Activities:
Net income	$ 1,147	$ 3,239
Adjustments to reconcile net income to net cash provided by operating activities:
Depreciation expense	160	157
Amortization expense	890	835
Stock-based compensation expense	295	305
Acquired in-process research and development expenses	338	205
In-process research and development impairment	2,700	0
Deferred income taxes	(944)	3
Net loss from equity securities	399	525
Other	420	529
Changes in operating assets and liabilities:
Accounts receivable, net	247	694
Inventories	61	(94)
Prepaid expenses and other	(30)	(2)
Accounts payable	(104)	(222)
Income taxes payable	(642)	(535)
Accrued and other liabilities	(1,295)	(713)
Net cash provided by operating activities	3,642	4,926
Investing Activities:
Purchases of marketable debt securities	(1,090)	(2,078)
Proceeds from sales of marketable debt securities	323	251
Proceeds from maturities of marketable debt securities	955	1,250
Acquisitions, including in-process research and development, net of cash acquired	(1,131)	(1,457)
Purchases of equity securities	(44)	(301)
Capital expenditures	(390)	(284)
Other	(1)	0
Net cash used in investing activities	(1,378)	(2,619)
Financing Activities:
Proceeds from issuances of common stock	97	100
Repurchases of common stock	(424)	(352)
Repayments of debt and other obligations	(500)	(1,250)
Payments of dividends	(1,865)	(1,811)
Other	(105)	(95)
Net cash used in financing activities	(2,797)	(3,408)
Effect of exchange rate changes on cash and cash equivalents	(66)	(3)
Net change in cash and cash equivalents	(599)	(1,104)
Cash and cash equivalents at beginning of period	5,338	5,997
Cash and cash equivalents at end of period	$ 4,739	$ 4,893