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Property, Plant and Equipment (Tables)
12 Months Ended
Dec. 31, 2020
Property, Plant and Equipment [Abstract]  
Property, plant and equipment
The following table summarizes our Property, plant and equipment, net:
December 31,
(in millions)20202019
Land and land improvements$404 $404 
Buildings and improvements (including leasehold improvements)3,678 3,358 
Laboratory and manufacturing equipment904 805 
Office, computer equipment and other793 634 
Construction in progress856 723 
Subtotal6,635 5,924 
Less: accumulated depreciation and amortization1,668 1,422 
Total$4,967 $4,502