CONSOLIDATED STATEMENTS OF OPERATIONS (USD $) In Thousands, except Per Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012
Revenue:
Net product revenue	$ 45,277	$ 23,718	$ 2,012
License and milestone revenue	38,614	55,838
Supply revenue	26,519	1,526
Royalty revenue	3,771
Total revenue	114,181	81,082	2,012
Operating expenses:
Cost of goods sold	33,387	4,868	187
Selling, general and administrative	111,539	158,235	109,665
Research and development	13,793	29,677	32,065
Inventory impairment and other non-recurring charges	6,173	42,916
Total operating expenses	164,892	235,696	141,917
Loss from operations	(50,711)	(154,614)	(139,905)
Interest and other expense (income):
Interest expense (income), net	32,535	19,532	(199)
Other expense	30	703
Total interest and other expense (income)	32,565	20,235	(199)
Loss from continuing operations before income taxes	(83,276)	(174,849)	(139,706)
(Benefit from) provision for income taxes	(629)	97	27
Loss from continuing operations before income taxes	(82,647)	(174,946)	(139,733)
Income (loss) from discontinued operations, net of tax		490	(148)
Net loss	$ (82,647)	$ (174,456)	$ (139,881)
Basic and diluted net loss per share:
Basic and Diluted net (loss) per share from Continuing operations	$ (0.80)	$ (1.72)	$ (1.42)
Discontinued operations (in dollars per share)	$ 0.00	$ 0.00	$ 0.00
Net loss per share (in dollars per share)	$ (0.80)	$ (1.72)	$ (1.42)
Shares used in per share computation:
Basic and diluted (in shares)	103,456	101,174	98,289