POWER OF ATTORNEY

		Known all by these presents, that the undersigned hereby
authorizes Daniel M. Bradbury, Mark G. Foletta, Marcea Bland Lloyd,
Lloyd A. Rowland or James R Oehler to execute for and on behalf of
the undersigned, in the undersigned's capacity as an executive officer
of Amylin Pharmaceuticals, Inc. (the "Company"), Forms 3, 4 and 5 of
any Amendments thereto, and cause such form(s) to be filed with the
Securities and Exchange Commission pursuant to Section 16(a) of the
Securities Exchange Act of 1934, relating to the undersigned's beneficial
ownership of securities in the Company.  The undersigned hereby grants
to such attorney-in-fact full power and authority to do and perform any
and every act and thing whatsoever requisite, necessary, or proper to be
done in the exercise of any of the rights and powers herein granted, as
fully to all intents and purposes as the undersigned might or could do if
personally present, with full power of substitution or revocation, hereby
ratifying and confirming all that such attorney-in-fact, or substitute or
substitutes of such attorney-in-fact, shall lawfully do or cause to be done
by virtue of this power of attorney and the rights and powers herein
granted.  The undersigned acknowledges that the foregoing attorney-in-fact,
in serving in such capacity at the request of the undersigned, is not
assuming, any of the undersigned's responsibilities to comply with Section 16
of the Securities Exchange Act of 1934.

		This Power of Attorney shall remain in full force and effect
until the undersigned is no longer required to file Forms 3, 4 and 5 with
respect to the undersigned's holdings of, and transactions in, securities
issued by the Company, unless earlier revoked by the undersigned in a
signed writing delivered to the foregoing attorney-in fact.

		IN WITNESS WHEREOF, the undersigned has caused this Power of
Attorney to be executed this 4 day of December, 2007.

						/s/ Jay S. Skyler, M.D., MACP
						Jay S. Skyler, M.D., MACP