Consolidated Statements Of Cash Flows (USD $) In Thousands	9 Months Ended
	Sep. 30, 2011	Sep. 30, 2010
Operating activities:
Net loss	$ (81,928)	$ (133,131)
Adjustments to reconcile net loss to net cash provided by (used for) operating activities:
Depreciation and amortization	36,866	42,443
Accretion of debt discount and amortization of debt issuance costs	11,263	9,143
Employee stock-based compensation	23,277	27,234
Stock-settled compensation accruals	12,915	15,631
Restructuring	645	833
Deferred revenue	(8,789)	(5,625)
Other non-cash expenses	4,213	4,060
Changes in operating assets and liabilities:
Accounts receivable	3,792	8,131
Inventories	12,215	8,313
Other current assets	7,716	13,526
Accounts payable and accrued liabilities	16,690	(13,823)
Accrued compensation	13,909	(24,307)
Payable to collaborative partner	5,542	(19,108)
Deferred collaborative profit sharing	15,986	27,053
Restructuring liabilities	(3,132)	(897)
Other assets and liabilities, net	(2,219)	(3,061)
Net cash flows provided by (used for) operating activities	68,961	(43,585)
Investing activities:
Purchases of short-term investments	(458,771)	(423,592)
Sales and maturities of short-term investments	398,403	589,222
Purchases of property, plant and equipment	(41,306)	(75,560)
Increase (decrease) in other long-term assets	2,295	(1,476)
Net cash flows (used for) provided by investing activities	(99,379)	88,594
Financing activities:
Issuance of common stock, net	8,294	15,233
Proceeds from loan payable to our collaborative partner	165,000
Repayment of convertible senior notes	(200,000)
Repayment of notes payable		(23,437)
Net cash flows used for financing activities	(26,706)	(8,204)
Change in cash and cash equivalents	(57,124)	36,805
Cash and cash equivalents at beginning of period	164,521	120,825
Cash and cash equivalents at end of period	107,397	157,630
Supplemental disclosure of cash flow information:
Property, plant and equipment additions in other current liabilities		572
Receivable arising from sale of property, plant and equipment		6,500
Non-cash dispositions of property, plant and equipment	296	0
Non-cash interest capitalized to property, plant and equipment	10,452	11,626
Non-cash financing activities:
Shares contributed as employer 401(k) match	3,956	3,851
Shares contributed to employee stock ownership plan	$ 16,456	$ 15,848