Consolidated Statements Of Cash Flows (USD $) In Thousands, unless otherwise specified	6 Months Ended
	Jun. 30, 2012	Jun. 30, 2011
Operating activities:
Net loss	$ (173,261)	$ (68,732)
Adjustments to reconcile net loss to net cash provided by (used for) operating activities:
Depreciation and amortization	46,684	25,265
Interest expense and debt discount accretion on promissory note related to revenue sharing obligation	68,783	0
Accretion of debt discount and amortization of debt issuance costs	10,896	8,092
Employee stock-based compensation	16,365	15,868
Stock-settled compensation accruals	11,552	8,582
Restructuring	5,512	645
Deferred revenue amortization	(3,750)	(3,750)
Change in fair value of assets and liabilities carried at fair value	10,650	0
Other non-cash expenses	68	4,028
Changes in operating assets and liabilities:
Accounts receivable	(9,140)	6,866
Inventories	(31,646)	15,423
Other current assets	11,117	13,387
Accounts payable and accrued liabilities	(120)	(671)
Accrued compensation	(14,143)	8,662
Payable to collaborative partner	(22,386)	3,921
Deferred collaborative profit-sharing	0	8,245
Restructuring liability	(6,117)	(3,696)
Other assets and liabilities, net	1,053	(437)
Long-term prepaid expenses	(4,618)	(706)
Net cash flows provided by (used for) operating activities	(82,501)	40,992
Investing activities:
Purchases of short-term investments	(257,841)	(284,658)
Sales and maturities of short-term investments	129,131	234,254
Increase of restrictedcCash	(154)	0
Purchases of property, plant and equipment	(21,502)	(25,237)
Increase (decrease) in other long-term assets	(909)	326
Net cash flows used for investing activities	(151,275)	(75,315)
Financing activities:
Issuance of common stock, net	235,241	5,399
Repayment of notes payable	(6,087)	0
Proceeds from note payable	0	165,000
Repayments of convertible senior notes	0	(200,000)
Net cash flows used by (used for) financing activities	229,154	(29,601)
Change in cash and cash equivalents	(4,622)	(63,924)
Cash and cash equivalents at beginning of period	99,859	164,521
Cash and cash equivalents at end of period	95,237	100,597
Supplemental disclosure of cash flow information:
Property, plant and equipment additions in other current liabilities	0	105
Non-cash dispositions of property, plant and equipment	0	247
Non-cash interest capitalized to property, plant and equipment	5,610	6,230
Non-cash financing activities:
Shares contributed as employer 401(k) match	3,243	3,956
Shares contributed to employee stock ownership plan	$ 13,253	$ 16,456