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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 LRscKG/6LQ3zp029w/gWWSOBKRftmMepxNrdg6fBNaPlZeMFGVHRSq2DwKDXN5cr
 oNxB9Nm0Fyy+LvCpa+cisw==

<SEC-DOCUMENT>0001193805-06-001219.txt : 20060515
<SEC-HEADER>0001193805-06-001219.hdr.sgml : 20060515
<ACCEPTANCE-DATETIME>20060515105730
ACCESSION NUMBER:		0001193805-06-001219
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20060512
FILED AS OF DATE:		20060515
DATE AS OF CHANGE:		20060515

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GENTA INC DE/
		CENTRAL INDEX KEY:			0000880643
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				330326866
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		TWO CONNELL DRIVE
		STREET 2:		..
		CITY:			BERKELEY HEIGHTS
		STATE:			NJ
		ZIP:			07922
		BUSINESS PHONE:		(908) 286-9800

	MAIL ADDRESS:	
		STREET 1:		TWO CONNELL DRIVE
		STREET 2:		..
		CITY:			BERKELEY HEIGHTS
		STATE:			NJ
		ZIP:			07922

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Driscoll Martin J
		CENTRAL INDEX KEY:			0001339402

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-19635
		FILM NUMBER:		06837691

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		908-286-3900

	MAIL ADDRESS:	
		STREET 1:		TWO CONNELL DRIVE
		CITY:			BERKELEY HEIGHTS
		STATE:			NJ
		ZIP:			07922
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>e600597_ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2006-05-12</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000880643</issuerCik>
        <issuerName>GENTA INC DE/</issuerName>
        <issuerTradingSymbol>GNTA</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001339402</rptOwnerCik>
            <rptOwnerName>Driscoll Martin J</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>TWO CONNELL DRIVE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BERKELEY HEIGHTS</rptOwnerCity>
            <rptOwnerState>NJ</rptOwnerState>
            <rptOwnerZipCode>07922</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock, par value $.001</value>
            </securityTitle>
            <transactionDate>
                <value>2006-05-12</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>15000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>1.46</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>15000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <ownerSignature>
        <signatureName>/s/ MARTIN J. DRISCOLL</signatureName>
        <signatureDate>2006-05-12</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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