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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 bM6CDTUgI9zvgs2WbkHo4Q==

<SEC-DOCUMENT>0001144204-08-069217.txt : 20081215
<SEC-HEADER>0001144204-08-069217.hdr.sgml : 20081215
<ACCEPTANCE-DATETIME>20081215061404
ACCESSION NUMBER:		0001144204-08-069217
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20081211
FILED AS OF DATE:		20081215
DATE AS OF CHANGE:		20081215

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MISONIX INC
		CENTRAL INDEX KEY:			0000880432
		STANDARD INDUSTRIAL CLASSIFICATION:	LABORATORY APPARATUS & FURNITURE [3821]
		IRS NUMBER:				112148932
		STATE OF INCORPORATION:			NY
		FISCAL YEAR END:			0630

	BUSINESS ADDRESS:	
		STREET 1:		1938 NEW HIGHWAY
		CITY:			FARMINGDALE
		STATE:			NY
		ZIP:			11747
		BUSINESS PHONE:		5166949555

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	MEDSONIC INC
		DATE OF NAME CHANGE:	19930328

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Napoli Frank
		CENTRAL INDEX KEY:			0001451521

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-10986
		FILM NUMBER:		081248533

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		631-694-9555

	MAIL ADDRESS:	
		STREET 1:		4 PINE MEADOW PLACE
		CITY:			COMMACK
		STATE:			NY
		ZIP:			11725
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>v134737_ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2008-12-11</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000880432</issuerCik>
        <issuerName>MISONIX INC</issuerName>
        <issuerTradingSymbol>MSON</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001451521</rptOwnerCik>
            <rptOwnerName>Napoli Frank</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>4 PINE MEADOW PLACE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>COMMACK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>11725</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>VP, Operations</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Stock Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.85</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2008-12-11</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>1000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                    <footnoteId id="F2"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2009-12-11</value>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2018-12-11</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock, par value $.01</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>1000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">The granted options vest in 25% increments on each of 12/11/2009, 12/11/2010, 12/11/2011 and 12/11/2012.</footnote>
        <footnote id="F2">Granted pursuant to issuer's stock option plans.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Frank Napoli</signatureName>
        <signatureDate>2008-12-15</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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