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Note 11 - Subsequent Events (Details Textual) - USD ($)
1 Months Ended 3 Months Ended 9 Months Ended
Nov. 03, 2022
Sep. 30, 2022
Sep. 30, 2021
Sep. 30, 2022
Sep. 30, 2021
Proceeds from Issuance of Common Stock       $ 3,267,000 $ 4,120,000
The 2020 Unit Offering [Member]          
Stock Issued During Period, Shares, New Issues (in shares)   3,766,126 388,889 13,568,524 3,820,436
Proceeds from Issuance of Common Stock   $ 632,000 $ 70,000 $ 2,364,000 $ 575,000
Subsequent Event [Member] | Warrants Expiring Six Month After Investment Date [Member]          
Warrants and Rights Outstanding, Term (Year) 6 months        
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right (in shares) 3,432,486        
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) $ 0.198        
Subsequent Event [Member] | Warrants Expiring Five Years After Investment Date [Member]          
Warrants and Rights Outstanding, Term (Year) 5 years        
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right (in shares) 3,432,486        
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) $ 0.248        
Subsequent Event [Member] | The 2020 Unit Offering [Member]          
Stock Issued During Period, Shares, New Issues (in shares) 3,432,486        
Proceeds from Issuance of Common Stock $ 567,000        
Lincoln Park Capital Fund, LLC [Member]          
Stock Issued During Period, Shares, New Issues (in shares)   2,440,958 2,917,819 4,353,919 21,444,128
Proceeds from Issuance of Common Stock   $ 485,000 $ 530,000 $ 903,000 $ 3,545,000
Lincoln Park Capital Fund, LLC [Member] | Subsequent Event [Member]          
Stock Issued During Period, Shares, New Issues (in shares) 479,546        
Proceeds from Issuance of Common Stock $ 107,000