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Note 13 - Summary of Stock Options (Details Textual) - USD ($)		1 Months Ended								12 Months Ended
	Aug. 22, 2016	Jun. 30, 2020	Jan. 31, 2020	Sep. 30, 2019	Jul. 31, 2019	Jun. 30, 2019	Apr. 30, 2019	Jan. 31, 2019	Aug. 31, 2017	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018	Jan. 01, 2020	Nov. 26, 2019	Jan. 01, 2019
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number, Ending Balance (in shares)										986,399	1,008,833	4,098
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price, Ending Balance (in dollars per share)										$ 19.10	$ 22.47	$ 4,567.36
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term (Year)										8 years 328 days	9 years 328 days	7 years 146 days
Proceeds from Stock Plans											$ 56,000
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross (in shares)										146,700	1,006,602
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Consultant [Member]
Stock Issued During Period, Shares, Restricted Stock Award, Gross (in shares)		25				25
Director [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period (in shares)					38		53
Stock Issued During Period, Shares, Restricted Stock Award, Gross (in shares)					38		53
Restricted Stock [Member] \| Director [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value (in dollars per share)					$ 380.80		$ 910
Share-based Payment Arrangement, Option [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate										0.00%
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total										$ 4,781,000
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition (Year)										2 years 182 days
The 2006 Stock Option Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number, Ending Balance (in shares)										12
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant (in shares)										0
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price, Ending Balance (in dollars per share)										$ 9,920
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term (Year)										2 years 36 days
The 2013 Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number, Ending Balance (in shares)										986,387
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant (in shares)										466,200
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price, Ending Balance (in dollars per share)										$ 18.98
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term (Year)										8 years 328 days
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period (Year)										10 years
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period (Year)										4 years
Share-based Compensation Arrangement by Share-based Payment Award, Percentage of Outstanding Stock Maximum										10.00%
Share-based Compensation Arrangement by Share-based Payment Award, Purchase Price of Common Stock, Percent										110.00%
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized, Percentage Increase of Outstanding Common Stock	4.00%
Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized (in shares)			263,993					2,044
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized (in shares)										1,451,246		4,914	1,451,246	1,187,253	6,958
Common Stock Shares Reserved For Future Issuance Percentage				18.00%
The 2013 Plan [Member] \| Employees and Nonemployees [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross (in shares)										146,700	1,006,602
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value (in dollars per share)										$ 4.08	$ 7.23
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period (in shares)										0	0
The 2013 Plan [Member] \| Restricted Stock [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number, Ending Balance (in shares)										234
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period (in shares)								384		0
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period (in shares)										18	132
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period (in shares)										0
The 2013 Plan [Member] \| Underwritten Public Offering [Member]
Minimum Gross Proceeds From Equity Offering Amount Used In Calculation Of Reserved Shares Percentage				$ 5,000,000
The 2013 Plan [Member] \| Holdings Greater Than 10 Percent of Shares Outstanding [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period (Year)										5 years
2017 Employee Stock Purchase Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Purchase Price of Common Stock, Percent									85.00%
Share-based Compensation Arrangement by Share-based Payment Award, Maximum Number of Shares Per Employee (in shares)									200
Stock Issued During Period, Shares, Employee Stock Purchase Plans (in shares)										84	154
Proceeds from Stock Plans										$ 1,000	$ 56,000
Employee Stock Ownership Plan (ESOP), Number of Suspense Shares (in shares)										22