Note 13 - Summary of Stock Options (Tables)

12 Months Ended

Dec. 31, 2020

Notes Tables

Share-based Payment Arrangement, Option, Activity [Table Text Block]

	Year Ended December 31, 2020
						Weighted
				Weighted		Average
	Number			Average		Remaining		Aggregate
	of			Exercise		Contractual		Intrinsic
	Shares			Price		Term (years)		Value
Options outstanding, January 1, 2019		4,098		$	4,567.36		7.4	$	-
Options granted		1,006,602		$	11.42
Options exercised		-
Options canceled		(1,867	)	$	4,040.64
Options outstanding, December 31, 2019		1,008,833		$	22.47		9.9	$	3,928,715
Options granted		146,700		$	6.36
Options exercised		-
Options canceled		(169,134	)	$	28.45
Options outstanding, December 31, 2020		986,399		$	19.10		8.9	$	675
Vested and exercisable and expected to vest, December 31, 2020		923,646		$	19.77		8.9	$	598
Vested and exercisable, December 31, 2020		245,445		$	45.09		8.6	$	-

Share-based Payment Arrangement, Option, Exercise Price Range [Table Text Block]

							Weighted
			Number		Weighted		Average		Number		Weighted
			Outstanding		Average		Remaining		Exercisable		Average
Range of			as of		Exercise		Contractual		as of		Exercise
Exercise Prices			December 31, 2020		Price		Term (Years)		December 31, 2020		Price
$4.45	-	$8.91		967,288	$	8.32		8.9		238,900	$	8.69
$10.90	-	$13.60		15,500	$	12.64		9.2		3,750	$	13.60
$380.00	-	$580.00		125	$	552.00		8.4		113	$	567.61
$1,000.00	-	$1,970.00		1,954	$	1,426.46		7.6		1,334	$	1,437.21
$2,020.00	-	$2,830.00		74	$	2,501.22		7.0		53	$	2,520.19
$3,110.00	-	$3,580.00		189	$	3,439.26		7.6		156	$	3,455.90
$4,360.00	-	$4,970.00		619	$	4,549.77		6.2		510	$	4,554.04
$5,010.00	-	$5,670.00		300	$	5,366.00		6.2		285	$	5,356.84
$6,000.00	-	$6,000.00		138	$	6,000.00		5.0		138	$	6,000.00
$7,140.00	-	$7,920.00		200	$	7,679.20		4.1		194	$	7,676.29
$9,920.00	-	$9,920.00		12	$	9,920.00		2.1		12	$	9,920.00
Total:				986,399	$	19.10		8.9		245,445	$	45.09

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

	Year Ended
	December 31,
	2020			2019
Expected term (in years)		5			6
Average volatility		82	%		70	%
Risk-free interest rate		0.37	%		1.62	%
Dividend yield		-			-

Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]

	Year Ended
	December 31,
	2020		2019
Cost of revenue	$	208	$	135
Research and development		325		192
Selling, general and administrative		2,118		2,073
Total	$	2,651	$	2,400