Note 10 - Summary of Stock Options - Valuation Assumptions for Stock Options (Details)	3 Months Ended	6 Months Ended
Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018
Expected term (Year)	5 years	5 years	5 years	5 years
Average volatility	75.00%	69.00%	73.00%	75.00%
Risk-free interest rate	2.03%	2.82%	2.49%	2.63%
Dividend yield	0.00%	0.00%	0.00%	0.00%
Nonemployees [Member]
Expected term (Year)		10 years	5 years	10 years
Average volatility		91.00%	73.00%	91.00%
Risk-free interest rate		2.85%	2.49%	2.85%
Dividend yield		0.00%	0.00%	0.00%

The estimated dividend rate (a percentage of the share price) to be paid (expected dividends) to holders of the underlying shares over the option's term.

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- Definition

The risk-free interest rate assumption that is used in valuing an option on its own shares.

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- Definition

Rate of weighted-average expected volatility for award under share-based payment arrangement.

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- Definition

Expected term of award under share-based payment arrangement, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

+ References

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-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
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