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Note 8 - Summary of Stock Options (Tables)
3 Months Ended
Mar. 31, 2015
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]
   

Three Months Ended March 31, 2015

 
                   

Weighted

         
           

Weighted

   

Average

   

Aggregate

 
   

Number

   

Average

   

Remaining

   

Intrinsic

 
   

of

   

Exercise

   

Contractual

   

Value

 
   

Shares

   

Price

   

Term (years)

   

(in thousands)

 
                                 

Options outstanding, beginning of period

    2,291,783     $ 1.02       9.32          

Options granted

    635,000     $ 0.47                  

Options exercised

    -     $ -                  

Options canceled

    (21,000 )   $ 1.00                  

Options outstanding, end of period

    2,905,783     $ 0.90       9.20     $ -  
                                 

Vested and exercisable and expected to vest, end of period

    2,664,185     $ 0.93       9.16     $ -  
                                 

Vested and exercisable, end of period

    608,492     $ 2.16       7.69     $ -  
Schedule of Share-based Compensation, Shares Authorized under Stock Option Plans, by Exercise Price Range [Table Text Block]
             

Options Outstanding

   

Options Exercisable

 
                             

Weighted

                 
             

Number

   

Weighted

   

Average

   

Number

   

Weighted

 
             

Outstanding

   

Average

   

Remaining

   

Exercisable

   

Average

 
 

Range of

   

as of

   

Exercise

   

Contractual

   

as of

   

Exercise

 
 

Exercise Prices

   

March 31, 2015

   

Price

   

Term (Years)

   

March 31, 2015

   

Price

 
                                                   
  $ 0.46 - $0.47       635,000     $ 0.47       9.86       -     $ -  
  $     0.60       1,881,476     $ 0.60       9.50       219,185     $ 0.60  
  $     1.24       312,373     $ 1.24       7.65       312,373     $ 1.24  
  $ 7.00 - $9.00       57,603     $ 8.64       2.58       57,603     $ 8.64  
  $ 12.00 - $18.63       19,081     $ 15.29       3.07       19,081     $ 15.29  
  $     37.00       250     $ 37.00       2.48       250     $ 37.00  
                2,905,783     $ 0.90       9.20       608,492     $ 2.16  
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
   

Three Months Ended

 
   

March 31,

 
   

2015

   

2014

 
                     

Expected term (in years)

    5         5    

Average volatility

    62%         67%    

Risk-free interest rate

  1.29% - 1.49%     0.80% - 0.88%  

Dividend yield

    0%         0%    
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]
   

Three Months Ended

 
   

March 31,

 
   

2015

   

2014

 
                 

Research and development

  $ 4     $ -  

Selling, general and administrative

    38       13  

Total

  $ 42     $ 13