Note 10 - Summary of Stock Options (Tables)

9 Months Ended

12 Months Ended

Sep. 30, 2014

Dec. 31, 2013

Note 10 - Summary of Stock Options (Tables) [Line Items]

Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]

	Outstanding Options
						Weighted-
				Weighted-		Average
	Number			Average		Remaining
	of			Exercise		Contractual
	Shares			Price		Term (years)
Options outstanding as of December 31, 2013		363,413		$	2.94		8.80
Options granted		1,901,476		$	0.60
Options assumed from PLC		68,238		$	10.24
Options canceled		(38,593	)	$	1.75
Options outstanding as of September 30, 2014		2,294,534		$	1.02		9.67

				Outstanding Options
									Weighted-
	Shares						Weighted-		Average
	Available			Number			Average		Remaining
	for			of			Exercise		Contractual
	Grant			Shares			Price		Term (years)
Shares reserved at plan inception		1,000,000			-		$	-
Options granted		(51,500	)		51,500			0.001
Balances as of December 31, 2006		948,500			51,500			0.001		9.96
Additional shares reserved		2,000,000			-			-
Options granted		(867,000	)		867,000			0.06
Options forfeited		5,000			(5,000	)		0.001
Balances as of December 31, 2007		2,086,500			913,500			0.06		9.82
Options granted		(72,500	)		72,500			0.06
Balances as of December 31, 2008		2,014,000			986,000			0.06		8.87
Options granted		(1,892,029	)		1,892,029			0.06
Options exercised		-			(322,395	)		0.06
Options forfeited		377,605			(377,605	)		0.06
Balances as of December 31, 2009		499,576			2,178,029			0.06		9.00
Additional shares reserved		461,957			-			-
Options granted		(771,412	)		771,412			0.05
Options exercised		-			(173,455	)		0.001
Options forfeited		12,500			(12,500	)		0.06
Balances as of December 31, 2010		202,621			2,763,486			0.06		8.40
Additional shares reserved		500,000			-			-
Options granted		(345,000	)		345,000			0.12
Options exercised		-			(9,000	)		0.001
Options forfeited		139,000			(139,000	)		0.06
Repurchase of restricted stock options		5,250			-
Balances as of December 31, 2011		501,871			2,960,486			0.07		7.70
Additional shares reserved		80,000,000			-			-
Options granted		(43,694,521	)		43,694,521			0.01
Options exercised		-			(1,866,903	)		0.07
Balances as of December 31, 2012		36,807,350			44,788,104			0.01		9.74
Options granted		(11,873,890	)		11,873,890			0.01
Options cancelled		11,515,876			(11,515,876	)		0.01
Balances as of December 31, 2013		36,449,336			45,146,118		$	0.01		8.80
Options vested and expected to vest as of December 31, 2013					43,338,910		$	0.01		8.80
Options vested as of December 31, 2013					15,025,985		$	0.02		8.60

Schedule of Share-based Compensation, Shares Authorized under Stock Option Plans, by Exercise Price Range [Table Text Block]

			Options Outstanding						Options Exercisable
							Weighted-
			Number		Weighted-		Average		Number		Weighted-
			Outstanding		Average		Remaining		Exercisable		Average
Range of			as of		Exercise		Contractual		as of		Exercise
Exercise Prices			September 30, 2014		Price		Term (Years)		September 30, 2014		Price
	$0.12			320	$	0.12		2.21		320	$	0.12
	$0.60			1,901,476	$	0.60		10.00		20,000	$	0.60
	$1.24			314,036	$	1.24		8.15		314,036	$	1.24
$7.00	-	$9.00		59,372	$	8.63		8.28		59,372	$	8.63
$12.00	-	$18.63		19,081	$	15.29		6.79		19,081	$	15.29
	$37.00			250	$	37.00		3.72		250	$	37.00
				2,294,535	$	1.02		9.67		413,059	$	2.94

		Options Outstanding				Options Vested
				Weighted-
				Average				Weighted-
				Remaining				Average
Exercise		Number		Contractual		Number		Exercise
Price		Outstanding		Life (Years)		of Options		Price
$	0.001		40,000		2.95		40,000	$	0.001
	0.06		980,250		5.68		921,104		0.06
	0.15		514,833		7.94		447,055		0.15
	0.01		43,611,035		8.89		13,617,826		0.01
			45,146,118		8.80		15,025,985	$	0.02

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

	Nine Months Ended
	September 30,
	2014		2013
Expected term (in years)		5		5
Average volatility		61%		67%
Risk-free interest rate		1.80%		0.87%
Dividend yield		0%		0%

Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]

	Three Months Ended September 30,				Nine Months Ended September 30,
	2014		2013		2014		2013
Research and development	$	101	$	976	$	667	$	(7,016	)
General and administrative		113,245		15,308		142,976		73,017
Total	$	113,346	$	16,284	$	143,643	$	66,001

Employee Stock Option [Member]

Note 10 - Summary of Stock Options (Tables) [Line Items]

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

							Cumulative for the Period
							September 21, 2005
							(Date of Inception) to
	2012			2013			December 31, 2013
Expected term (in years)		5.00			5.00			5.00 - 6.25
Expected volatility		68	%		67	%		60% - 79	%
Risk-free interest rate		0.76% - 0.84	%		0.84	%		0.76% - 4.7	%
Dividend yield		0	%		0	%		0	%

Nonemployee Stock Option [Member]

Note 10 - Summary of Stock Options (Tables) [Line Items]

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

					Cumulative for the Period
					September 21, 2005
					(Date of Inception) to
	2012		2013		December 31, 2013
Contractual term (in years)		4 - 10		3 - 10		3 - 10
Expected volatility		68%		67%		60% - 79%
Risk-free interest rate		0.72% - 1.78%		0.78% - 3.04%		0.56% - 4.7%
Dividend yield		0%		0%		0%