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License agreements - Innovent (Details) - Innovent - USD ($)
$ in Millions
1 Months Ended 3 Months Ended 6 Months Ended
Apr. 30, 2020
Jun. 30, 2019
Jan. 31, 2019
Dec. 31, 2018
Jun. 30, 2020
Jun. 30, 2019
Jun. 30, 2020
Jun. 30, 2019
Dec. 31, 2019
License agreements                  
Upfront and immediate milestone payment to be received under license agreement     $ 40.0            
Research and development expenses reimbursed         $ 2.6 $ 0.5 $ 2.6 $ 0.5  
Reimbursable costs included in accounts receivable         $ 2.2   $ 2.2   $ 3.0
Regulatory Milestones                  
License agreements                  
Amount recognized and received for the achievement of a predefined milestone   $ 20.0              
Regulatory Milestones | PEMAZYRE                  
License agreements                  
Amount recognized and received for the achievement of a predefined milestone $ 5.0                
Development and Regulatory Milestones | Maximum                  
License agreements                  
Upfront and immediate milestone payment to be received under license agreement       $ 129.0          
Sales and Commercial Milestones | Maximum                  
License agreements                  
Upfront and immediate milestone payment to be received under license agreement       $ 202.5