CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2020	Mar. 31, 2019
Revenues:
Total revenues	$ 568,507	$ 497,857
Costs and expenses:
Cost of product revenues (including definite-lived intangible amortization)	27,319	22,588
Research and development	1,085,287	270,545
Selling, general and administrative	111,148	123,983
Change in fair value of acquisition-related contingent consideration	6,627	6,671
Collaboration loss sharing	2,130
Total costs and expenses	1,232,511	423,787
Income (loss) from operations	(664,004)	74,070
Other income (expense), net	8,662	9,373
Interest expense	(602)	(335)
Unrealized gain (loss) on long term investments	(48,132)	20,989
Income (loss) before provision for income taxes	(704,076)	104,097
Provision for income taxes	16,566	1,785
Net (loss) income	$ (720,642)	$ 102,312
Net income (loss) per share:
Basic	$ (3.33)	$ 0.48
Diluted	$ (3.33)	$ 0.47
Shares used in computing net income (loss) per share:
Basic	216,721	214,065
Diluted	216,721	217,061
Product revenues, net
Revenues:
Total revenues	$ 486,727	$ 396,249
Product royalty revenues
Revenues:
Total revenues	$ 81,780	61,608
Milestone and contract revenues
Revenues:
Total revenues		$ 40,000