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Income Taxes - Reconciliation of income taxes (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Reconciliation of income taxes at the U.S. federal statutory rate to the provision for income taxes      
Provision (benefit) at U.S. federal statutory rate $ 102,226 $ 24,223 $ (109,302)
Unbenefited net operating losses and tax credits (82,819) (51,861) (99,254)
Excess tax benefits related to share-based compensation (13,418) (8,233) (81,021)
Deferred tax impact of Tax Cuts and Jobs Act of 2017     196,751
Foreign tax rate differential 25,419 37,061 86,777
Non-deductible officer compensation 5,213 4,114 6,351
Other 3,264 550 550
Provision for income taxes $ 39,885 $ 5,854 $ 852
Federal corporate tax rate (as a percent) 21.00% 21.00% 35.00%
Deferred tax assets:      
Net operating loss carry forwards $ 102,001 $ 148,142  
Federal and state research credits 400,550 402,798  
Capitalized research and development 46,188 53,871  
Deferred revenue and accruals 13,609 9,443  
Non-cash compensation 67,345 58,194  
Acquisition-related contingent consideration 31,956 43,676  
Intangibles, net 92,806 93,730  
Long term investments 14,899 23,621  
Other 21,885 22,211  
Total gross deferred tax assets 791,239 855,686  
Less valuation allowance for deferred tax assets (770,497) (836,992)  
Net deferred tax assets 20,742 18,694  
Deferred tax liabilities:      
Property and equipment (19,095) (17,424)  
Total gross deferred tax liabilities (19,095) (17,424)  
Net deferred tax assets $ 1,647 $ 1,270