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License agreements - Innovent (Details) - Innovent
$ in Millions
1 Months Ended 12 Months Ended
Jun. 30, 2019
USD ($)
Jan. 31, 2019
USD ($)
Dec. 31, 2018
USD ($)
item
Dec. 31, 2019
USD ($)
License agreements        
Upfront and immediate milestone payment to be received under license agreement   $ 40.0    
Research and development expenses reimbursed       $ 6.2
Reimbursable costs included in accounts receivable       $ 3.0
Product candidates | item     3  
Regulatory Milestones        
License agreements        
Milestone payment made under license agreement $ 20.0      
Regulatory Milestones | Maximum        
License agreements        
Upfront and immediate milestone payment to be received under license agreement     $ 20.0  
Development and Regulatory Milestones | Maximum        
License agreements        
Upfront and immediate milestone payment to be received under license agreement     129.0  
Commercialization Milestones | Maximum        
License agreements        
Upfront and immediate milestone payment to be received under license agreement     $ 202.5