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License agreements - Lilly (Details)
$ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended 12 Months Ended 118 Months Ended
May 31, 2019
USD ($)
Mar. 31, 2016
USD ($)
Dec. 31, 2009
USD ($)
item
Sep. 30, 2019
USD ($)
Sep. 30, 2018
USD ($)
Sep. 30, 2019
USD ($)
Sep. 30, 2018
USD ($)
Dec. 31, 2018
USD ($)
Dec. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
Dec. 31, 2012
USD ($)
Dec. 31, 2010
USD ($)
Sep. 30, 2019
USD ($)
License agreements                          
Research and Development Expense       $ 281,336 $ 292,527 $ 841,244 $ 893,719            
Revenues       551,581 449,683 1,579,370 1,353,481            
Product royalty revenues                          
License agreements                          
Revenues       80,083 61,923 217,726 165,592            
Eli Lilly                          
License agreements                          
Upfront payment received under license agreement     $ 90,000                    
Number of deliverables under license agreement | item     2                    
Product royalties in accounts receivable       $ 21,700   $ 21,700   $ 14,000         $ 21,700
Eli Lilly | Phase IIB                          
License agreements                          
Funding of future development costs (as a percent)       30.00%   30.00%              
Research and Development Expense         18,900   45,600            
Accrued and other liabilities               23,100          
Eli Lilly | Pre-specified Events | Maximum                          
License agreements                          
Upfront and immediate milestone payment to be received under license agreement     $ 665,000                    
Eli Lilly | Development Milestones                          
License agreements                          
Amount recognized and received for the achievement of a predefined milestone               20,000 $ 30,000       149,000
Eli Lilly | Development Milestones | Maximum                          
License agreements                          
Upfront and immediate milestone payment to be received under license agreement     150,000                    
Eli Lilly | Development Milestones | Phase III                          
License agreements                          
Amount recognized and received for the achievement of a predefined milestone                     $ 50,000    
Eli Lilly | Development Milestones | Phase IIA                          
License agreements                          
Amount recognized and received for the achievement of a predefined milestone                       $ 30,000  
Eli Lilly | Development Milestones | Phase IIB                          
License agreements                          
Amount recognized and received for the achievement of a predefined milestone                       $ 19,000  
Eli Lilly | Regulatory Milestones                          
License agreements                          
Amount recognized and received for the achievement of a predefined milestone               $ 100,000         $ 235,000
Eli Lilly | Regulatory Milestones | JAPAN                          
License agreements                          
Amount recognized and received for the achievement of a predefined milestone                 15,000        
Eli Lilly | Regulatory Milestones | U.S.                          
License agreements                          
Amount recognized and received for the achievement of a predefined milestone                   $ 35,000      
Eli Lilly | Regulatory Milestones | Europe                          
License agreements                          
Amount recognized and received for the achievement of a predefined milestone                 $ 65,000 $ 20,000      
Eli Lilly | Regulatory Milestones | Maximum                          
License agreements                          
Upfront and immediate milestone payment to be received under license agreement     365,000                    
Eli Lilly | Commercialization Milestones | Maximum                          
License agreements                          
Upfront and immediate milestone payment to be received under license agreement     $ 150,000                    
Eli Lilly | GVHD                          
License agreements                          
Upfront payment under license agreement   $ 35,000                      
Additional milestone payments under the license agreement   $ 40,000                      
Eli Lilly | GVHD | Regulatory Milestones                          
License agreements                          
Milestone payment made under license agreement $ 20,000                        
Eli Lilly | Product royalty revenues                          
License agreements                          
Revenues       $ 21,600 11,000 $ 56,800 26,200            
Eli Lilly | Milestone revenues                          
License agreements                          
Revenues       $ 0 $ 20,000 $ 0 $ 120,000