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License agreements - MacroGenics (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 6 Months Ended
Nov. 30, 2018
Sep. 30, 2018
Dec. 31, 2017
Jun. 30, 2019
Jun. 30, 2018
Jun. 30, 2019
Jun. 30, 2018
Dec. 31, 2018
License agreements                
Research and development       $ 289,363 $ 298,089 $ 559,908 $ 601,192  
MacroGenics                
License agreements                
Upfront payment under license agreement     $ 150,000          
Research and development $ 5,000 $ 10,000   9,800 $ 10,900 19,200 $ 17,400  
MacroGenics | Accrued and other liabilities                
License agreements                
Accrued and other liabilities       $ 2,600   $ 2,600   $ 3,200
Minimum | MacroGenics                
License agreements                
Royalty payments on future global net sales (as a percent)     15.00%          
Maximum | MacroGenics                
License agreements                
Royalty payments on future global net sales (as a percent)     24.00%          
Development and Regulatory Milestones | Maximum | MacroGenics                
License agreements                
Additional milestone payments under the license agreement     $ 420,000          
Commercialization Milestones | Minimum | MacroGenics                
License agreements                
Additional milestone payments under the license agreement     $ 330,000