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Fair value of financial instruments - Fair value on a recurring basis (Details) (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended 12 Months Ended
Jun. 30, 2019
Mar. 31, 2019
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2019
Dec. 31, 2018
Fair value of financial instruments            
Assets transfers from Level 1 to Level 2 $ 0       $ 0  
Assets transfers from Level 2 to Level 1 0       0  
Assets transfers into Level 3         0  
Assets transfers out of Level 3         0  
Liabilities transfers from Level 1 to Level 2 0       0  
Liabilities transfers from Level 2 to Level 1 0       0  
Liabilities transfers into Level 3         0  
Liabilities transfers out of Level 3         0  
Long term investments 115,563   $ 99,199   115,563 $ 99,199
ARIAD            
Roll forward of Level 3 liabilities            
Contingent consideration earned during the period but not yet paid (7,600)         (13,200)
ARIAD | Account payable            
Roll forward of Level 3 liabilities            
Contingent consideration earned during the period but not yet paid       $ (6,700)    
ARIAD | Accrued and other current liabilities            
Roll forward of Level 3 liabilities            
Contingent consideration earned during the period but not yet paid (7,600) $ (6,700) (6,500)      
Level 3 | Fair Value            
Roll forward of Level 3 liabilities            
Balance at the beginning of the period   $ 287,001     287,001  
Contingent consideration earned during the period but not yet paid         (7,608)  
Payments made during the period         (6,672)  
Change in fair value of contingent consideration         13,279  
Balance at the end of the period 286,000   287,001   286,000 287,001
Recurring | Fair Value            
Fair value of financial instruments            
Cash and cash equivalents 1,416,224   1,163,980   1,416,224 1,163,980
Debt securities (corporate and government) 279,631   274,343   279,631 274,343
Long term investments 115,563   99,199   115,563 99,199
Total assets 1,811,418   1,537,522   1,811,418 1,537,522
Acquisition-related contingent consideration 286,000   287,001   286,000 287,001
Total liabilities 286,000   287,001   286,000 287,001
Recurring | Level 1            
Fair value of financial instruments            
Cash and cash equivalents 1,416,224   1,163,980   1,416,224 1,163,980
Long term investments 115,563   99,199   115,563 99,199
Total assets 1,531,787   1,263,179   1,531,787 1,263,179
Recurring | Level 2            
Fair value of financial instruments            
Debt securities (corporate and government) 279,631   274,343   279,631 274,343
Total assets 279,631   274,343   279,631 274,343
Recurring | Level 3            
Fair value of financial instruments            
Acquisition-related contingent consideration 286,000   287,001   286,000 287,001
Total liabilities $ 286,000   $ 287,001   $ 286,000 $ 287,001