CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016
Revenues:
Product revenues, net	$ 291,667	$ 212,116	$ 556,474	$ 395,383
Product royalty revenues	34,769	25,958	63,990	47,860
Contract revenues		8,214	90,000	66,429
Other revenues	8		62	80
Total revenues	326,444	246,288	710,526	509,752
Costs and expenses:
Cost of product revenues (including definite-lived intangible amortization)	20,260	12,367	35,084	18,372
Research and development	201,839	120,269	609,811	277,092
Selling, general and administrative	90,072	66,792	177,306	131,390
Change in fair value of acquisition-related contingent consideration	7,073	2,271	14,429	2,271
Total costs and expenses	319,244	201,699	836,630	429,125
Income (loss) from operations	7,200	44,589	(126,104)	80,627
Interest and other income, net	4,125	1,137	5,329	2,630
Interest expense	(384)	(9,662)	(6,323)	(19,796)
Unrealized loss on long term investments	(19,574)	(854)	(25,388)	(3,804)
Expense related to senior note conversions	(751)		(54,881)
Income (loss) before provision (benefit) for income taxes	(9,384)	35,210	(207,367)	59,657
Provision (benefit) for income taxes	3,100	785	(7,800)	1,185
Net income (loss)	$ (12,484)	$ 34,425	$ (199,567)	$ 58,472
Net income (loss) per share:
Basic	$ (0.06)	$ 0.18	$ (1.00)	$ 0.31
Diluted	$ (0.06)	$ 0.18	$ (1.00)	$ 0.30
Shares used in computing net income (loss) per share:
Basic	205,141	187,682	200,200	187,433
Diluted	205,141	193,015	200,200	192,820