CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2015	Sep. 30, 2014	Sep. 30, 2015	Sep. 30, 2014
Revenues:
Product revenues, net	$ 161,259	$ 97,837	$ 418,994	$ 251,513
Product royalty revenues	18,138	12,093	51,175	34,259
Contract revenues	8,214	88,214	39,643	101,643
Other revenues		3	58	107
Total revenues	187,611	198,147	509,870	387,522
Costs and expenses:
Cost of product revenues	8,040	221	17,268	576
Research and development	132,073	88,537	362,882	248,806
Selling, general and administrative	47,599	39,446	144,147	117,320
Total costs and expenses	187,712	128,204	524,297	366,702
Income (loss) from operations	(101)	69,943	(14,427)	20,820
Interest and other income, net	3,026	885	5,800	2,410
Interest expense	(11,209)	(11,463)	(35,390)	(34,312)
Unrealized gain on long term investment	(31,289)		(4,115)
Debt exchange expense on senior note conversions				(265)
Income (loss) before provision for income taxes	(39,573)	59,365	(48,132)	(11,347)
Provision for income taxes	9	72	513	191
Net income (loss)	$ (39,582)	$ 59,293	$ (48,645)	$ (11,538)
Net income (loss) per share:
Basic (in dollars per share)	$ (0.22)	$ 0.35	$ (0.27)	$ (0.07)
Diluted (in dollars per share)	$ (0.22)	$ 0.33	$ (0.27)	$ (0.07)
Shares used in computing net income (loss) per share:
Basic (in shares)	181,387	168,592	177,378	167,288
Diluted (in shares)	181,387	189,046	177,378	167,288