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Net loss per share (Details) (USD $)
 3 Months Ended 6 Months Ended 3 Months Ended 6 Months Ended 2 Months Ended 3 Months Ended 6 Months Ended 1 Months Ended 3 Months Ended 6 Months Ended 3 Months Ended 6 Months Ended
Jun. 30, 2013
Jun. 30, 2012
Jun. 30, 2013
Jun. 30, 2012
Jun. 30, 2013
Stock options
Jun. 30, 2012
Stock options
Jun. 30, 2013
Stock options
Jun. 30, 2012
Stock options
Jun. 30, 2013
4.75% Senior Notes
Jun. 30, 2013
4.75% Senior Notes
Jun. 30, 2012
4.75% Senior Notes
Jun. 30, 2013
4.75% Senior Notes
Jun. 30, 2012
4.75% Senior Notes
Dec. 31, 2012
Pfizer Note due 2013
Jun. 30, 2012
Pfizer Note due 2013
Jun. 30, 2012
Pfizer Note due 2013
Jun. 30, 2013
Pfizer Note due 2014
Jun. 30, 2012
Pfizer Note due 2014
Jun. 30, 2013
Pfizer Note due 2014
Jun. 30, 2012
Pfizer Note due 2014
Basic Net Income (Loss) Per Share                                        
Net income (loss) $ (2,571,000) $ 4,037,000 $ (18,240,000) $ (41,389,000)                                
Weighted average common shares outstanding (in shares) 142,284,000 129,224,000 138,315,000 128,214,000                                
Basic net income (loss) per share (in dollars per share) $ (0.02) $ 0.03 $ (0.13) $ (0.32)                                
Diluted Net Income (Loss) Per Share                                        
Diluted net income (loss) (in dollars) (2,571,000) 4,037,000 (18,240,000) (41,389,000)                                
Common shares outstanding (weighted average) (in shares) 142,284,000 129,224,000 138,315,000 128,214,000                                
Dilutive stock options (in shares)   8,745,000                                    
Weighted average shares used to compute diluted net income (loss) per share (in shares) 142,284,000 137,969,000 138,315,000 128,214,000                                
Diluted net income (loss) per share (in dollars per share) $ (0.02) $ 0.03 $ (0.13) $ (0.32)                                
Anti-dilutive securities                                        
Interest rate of debt (as a percent)                 4.75% 4.75% 4.75% 4.75% 4.75%              
Potential common shares excluded from diluted net loss per share computation 53,931,768 53,271,441 53,931,768 71,345,865 23,698,488 5,200,264 23,698,488 23,274,688   29,207,639 45,584,040 29,207,639 45,584,040   1,461,496 1,461,496 1,025,641 1,025,641 1,025,641 1,025,641
Aggregate principal amount of notes to be converted                 $ 143,700,000         $ 10,000,000            
Common stock issued in conversion of notes (in shares)                 16,376,175         1,461,496