CONSOLIDATED STATEMENT OF STOCKHOLDERS' DEFICIT (USD $) In Thousands, unless otherwise specified	Total	Common Stock	Additional Paid-in Capital	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit
Balances at Dec. 31, 2009	$ (102,384)	$ 119	$ 1,287,974	$ 707	$ (1,391,184)
Increase (Decrease) in Stockholders' Equity
Issuance of 5,150,649, 2,294,586 and 1,701,368 shares of Common Stock upon exercise of stock options and restricted stock units and 378,041, 896,939 and 1,182,929 shares of Common Stock under the ESPP for the years ended 2012, 2011 and 2010, respectively	13,589	3	13,586
Issuance of 1,461,496 and 1,502,851 shares of Common Stock upon conversion of convertible senior and subordinated notes, and Pfizer Note for the years ended 2012 and 2010, respectively	15,862	1	15,861
Stock compensation expense	14,856		14,856
Other comprehensive (loss) income	1,279			1,279
Net loss	(31,846)				(31,846)
Balances at Dec. 31, 2010	(88,644)	123	1,332,277	1,986	(1,423,030)
Increase (Decrease) in Stockholders' Equity
Issuance of 5,150,649, 2,294,586 and 1,701,368 shares of Common Stock upon exercise of stock options and restricted stock units and 378,041, 896,939 and 1,182,929 shares of Common Stock under the ESPP for the years ended 2012, 2011 and 2010, respectively	19,468	3	19,465
Stock compensation expense	28,983		28,983
Other comprehensive (loss) income	(344)			(344)
Net loss	(186,540)				(186,540)
Balances at Dec. 31, 2011	(227,077)	126	1,380,725	1,642	(1,609,570)
Increase (Decrease) in Stockholders' Equity
Issuance of 5,150,649, 2,294,586 and 1,701,368 shares of Common Stock upon exercise of stock options and restricted stock units and 378,041, 896,939 and 1,182,929 shares of Common Stock under the ESPP for the years ended 2012, 2011 and 2010, respectively	47,711	5	47,706
Issuance of 1,461,496 and 1,502,851 shares of Common Stock upon conversion of convertible senior and subordinated notes, and Pfizer Note for the years ended 2012 and 2010, respectively	10,000	2	9,998
Stock compensation expense	38,493		38,493
Other comprehensive (loss) income	236			236
Net loss	(44,320)				(44,320)
Balances at Dec. 31, 2012	$ (174,957)	$ 133	$ 1,476,922	$ 1,878	$ (1,653,890)